gms | German Medical Science

69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

03.06. - 06.06.2018, Münster

Cortical plasticity of language function in glioma patients as measured by nrTMS

Meeting Abstract

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  • Sebastian Ille - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Deutschland
  • Lara Engel - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Deutschland
  • Nico Sollmann - Institut für Radiologie, Abteilung für diagnostische und interventionelle Neuroradiologie, Klinikum rechts der Isar, Technische Universität München, München, Deutschland
  • Bernhard Meyer - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Deutschland
  • Sandro Krieg - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Deutschland

Deutsche Gesellschaft für Neurochirurgie. 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie. Münster, 03.-06.06.2018. Düsseldorf: German Medical Science GMS Publishing House; 2018. DocV069

doi: 10.3205/18dgnc070, urn:nbn:de:0183-18dgnc0709

Veröffentlicht: 18. Juni 2018

© 2018 Ille et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Objective: Cortical plasticity has been shown in glioma patients by direct cortical stimulation (DCS) during awake craniotomy. However, this invasive option for repeated mapping is only available in case of tumor recurrence and after decision for a second surgery. Navigated repetitive transcranial magnetic stimulation (nrTMS) has shown a high correlation to the results of DCS during awake craniotomy for language-negative regions. The present study aims to examine the cortical plasticity of language-negative regions in glioma patients.

Methods: We included 14 patients with left-sided perisylvian gliomas who underwent preoperative nrTMS language mapping twice. The mean time between mappings was 17 ± 12 months. Cortex was separated into anterior (A) and posterior (P) language-eloquent regions. In order to perform analysis we defined a tumor area (T) and an area without tumor (WOT) based on the subdivision into A and P regions.

Results: We detected changes of cortical language function in all patients. In 8 of 14 patients (57.1%) we found more language-negative regions within the T area during the second nrTMS mapping (26 vs. 11 during first mapping). Three patients (21.4%) showed no change of language-negative cortical regions. In three patients (21.4%) nrTMS detected less language-negative regions within the T area during the second mapping (22 vs. 34 during the first mapping).

Conclusion: Present results show that nrTMS might be able to show cortical plasticity of language-negative regions in glioma patients. However, the reliability of our results has to be confirmed in a larger cohort and by DCS during awake craniotomy.