Artikel
The role of ABO blood group in subarachnoid hemorrhage
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Veröffentlicht: | 9. Juni 2017 |
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Gliederung
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Objective: Rupture of an intracranial aneurysm usually presents with an acute onset, requires multidisciplinary intensive care treatment, and the overall death and disability rates are high. The ABO blood type is known to play an important role in hemostasis, thrombosis and vascular NO response. The aspect of ABO blood type in onset, clinical progress and outcome after SAH are to date largely unexplored. We conducted this study to elucidate the association of ABO blood type on the occurrence and outcome of aneurysmal SAH.
Methods: In our retrospective study 470 aneurysmal SAH-patients treated at our institution were included. We performed a chi-squared test (χ2-test) for comparison between blood types and WFNS admission status, cerebral vasospasm, delayed infarction and associated intracerebral hemorrhage and fisher grade for analysis for their association with SAH.
Results: No significant difference between blood type and the reviewed variables for SAH outcome were identified. WFNS admission status. (Odds ratio: 1.12 95% CI: 0.7-1.6 p: 0.56). SAH-associated ICH (Odds ratio: 0.81 95% CI: 0.5-1.3 p: 0.36). Cerebral vasospasm (Odds ratio: 1.08 95% CI: 0.7-1.6 p: 0.71). (Odds ratio: 1.23 95% CI: 0.8-1.8 p: 0.30). Fisher grade (Odds ratio: 1.13 95% CI: 0.7-1.6 p: 0.19)
Conclusion: Although a possible relationship between the ABO blood group and the clinical course of SAH patients was hypothesized, our study showed no significant influence of patient’s ABO blood type on cerebral vasospasm onset, SAH-associated intracerebral hemorrhage or delayed infarction.