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68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
7. Joint Meeting mit der Britischen Gesellschaft für Neurochirurgie (SBNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

14. - 17. Mai 2017, Magdeburg

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Cerebrovascular manipulation leads to excessive release of endogenous Neuropeptide Y

Meeting Abstract

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  • Karl-Michael Schebesch - Klinikum der Universität Regensburg, Klinik und Poliklinik für Neurochirurgie, Regensburg, Deutschland
  • Elisabeth Bründl - Regensburg, Deutschland
  • Petra Schödel - Department of Neurosurgery, Regensburg, Deutschland
  • Judith Scheitzach - Dept. of Neurosurgery, Regensburg University Medical Center, Regensburg, Deutschland
  • Sylvia Bele - Dept. of Neurosurgery, Regensburg University Medical Center, Regensburg, Deutschland
  • Alexander T. Brawanski - Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Regensburg, Regensburg, Deutschland
  • Martin A. Proescholdt - Universitätsklinikum Regensburg, Klinik für Neurochirurgie, Regensburg, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocMi.01.07

doi: 10.3205/17dgnc359, urn:nbn:de:0183-17dgnc3591

Veröffentlicht: 9. Juni 2017

© 2017 Schebesch et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: Neuropeptide Y (NPY), mainly responsible for the cerebro-vascular tone under physiologic conditions, is stored in perivascular nerve fibers around cerebral arteries and its excessive release due to subarachnoid hemorrhage has been shown repeatedly. In this prospective study we sought to evaluate the levels of NPY over time due to surgical and endovascular manipulation of the cerebral vasculature.

Methods: Prospectively, 38 patients have been included (m:f=21:17; mean age 51.3 years). Anterior circulation aneurysms (=vascular group), were treated in 24 patients (endovascular subgroup n=12, clipping subgroup n=12) and the levels of NPY in plasma were compared to 14 patients in the non-vascular group (lumbar disc herniation subgroup n=10, convexity meningioma subgroup n=4) at different time points: 1) day before surgery, 2) intraoperatively, 3) 6 hours postop., 4) 72 hours postop., and 5) 40 days postop. Plasma levels of NPY were determined by means of a competitive enzyme immunoassay (EIA).

Results: Except for time point 1 and 3, the levels of NPY ranged significantly higher in the vascular group compared to the non-vascular group. In the subgroup analysis, the levels of NPY in the clipping subgroup were the highest during the complete observational period, reaching statistical significance (p=0.026).

Conclusion: To the best of our knowledge, this study is the first to prospectively evaluate the plasma levels of endogenous NPY in neurosurgical patients. The results impressively show the excessive release of NPY due to direct manipulation of cerebral arteries. This could be a novel approach towards a better understanding of functional outcome in patients with cerebro-vascular malformations