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68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
7. Joint Meeting mit der Britischen Gesellschaft für Neurochirurgie (SBNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

14. - 17. Mai 2017, Magdeburg

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Early plasma creatinine levels after aneurysmal subarachnoid hemorrhage correlate with functional neurological outcome – a single center series

Meeting Abstract

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  • Tamara Kern - Klinik für Neurochirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland
  • Patrick Schuss - Klinik für Neurochirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland
  • Alexis Hadjiathanasiou - Klinik für Neurochirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland
  • Felix Lehmann - Klinik für Anästhesiologie und Intensivmedizin, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland
  • Ági Güresir - Klinik für Neurochirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland
  • Hartmut Vatter - Klinik für Neurochirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland
  • Erdem Güresir - Klinik für Neurochirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocDI.12.05

doi: 10.3205/17dgnc245, urn:nbn:de:0183-17dgnc2450

Veröffentlicht: 9. Juni 2017

© 2017 Kern et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: Acute kidney injury is common in critically ill patients and may contribute to poor outcome. However, data on the potential influence of early plasma creatinine (pCr) in patients suffering from aneurysmal subarachnoid hemorrhage (SAH) on neurological outcome is scarce. We therefore analyzed our neurovascular database in order to study the association between early pCr and functional outcome after SAH.

Methods: From 2011 to April 2016, 330 patients suffering from aneurysmal SAH were treated at the authors institution and included in this retrospective cohort study. Information, including patient characteristics, treatment modality, aneurysm size and location, laboratory values, radiological features, and functional neurological outcome were assessed and further analyzed. Patients suffering from SAH were divided into good-grade (WFNS I-III) versus poor-grade (WFNS IV-V) on admission. Outcome was assessed according to the modified Rankin Scale (mRS) at 6 months and stratified into favourable (mRS 0-2) versus unfavourable (mRS 3-6).

Results: Overall 163 of 330 patients suffering from aneurysmal SAH achieved favourable outcome (49%). Patients with SAH and initial pCr levels ≤ 0.8 mg/dl achieved significantly more often favourable outcome compared to patients with SAH and initial pCr levels > 0.8 mg/dl (p=0.01). Patients suffering from poor-grade SAH had significantly higher levels of initial pCr, when compared to patients with good-grade SAH (p=0.02).

Conclusion: We demonstrated that increased initial plasma creatinine levels are associated with unfavourable functional outcome after SAH. The present study highlights the necessity of close surveillance of renal function in the aneurysmal subarachnoid hemorrhage population.