gms | German Medical Science

66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Friendship Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

7. - 10. Juni 2015, Karlsruhe

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Cortical regions involved in semantic processing investigated by repetitive navigated transcranial magnetic stimulation and object naming

Meeting Abstract

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  • Nico Sollmann - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München
  • Theresa Hauck - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München
  • Florian Ringel - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München
  • Bernhard Meyer - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München
  • Sandro M. Krieg - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München

Deutsche Gesellschaft für Neurochirurgie. 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Karlsruhe, 07.-10.06.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. DocMI.18.05

doi: 10.3205/15dgnc393, urn:nbn:de:0183-15dgnc3936

Veröffentlicht: 2. Juni 2015

© 2015 Sollmann et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

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Objective: Knowledge about the cortical representation of semantic processing is mainly derived from functional magnetic resonance imaging (fMRI) or direct cortical stimulation (DCS) studies. Because DCS is regarded as the gold standard in terms of language mapping but can only be used during awake surgery due to its invasive character, repetitive navigated transcranial magnetic stimulation (rTMS) – a non-invasive modality that uses a similar technique as DCS – seems highly feasible for use in the investigation of semantic processing in the healthy human brain.

Method: A total number of 150 (80 left-hemispheric and 70 right-hemispheric) rTMS-based language mappings were performed in purely right-handed, healthy volunteers during an object-naming task. All rTMS-induced semantic naming errors were then evaluated systematically, counted, and related to their cortical sites by projecting the mapping results into the cortical parcellation system (CPS).

Results: Overall, the most left-hemispheric semantic errors were observed after targeting the rTMS to the posterior middle temporal gyrus (pMTG; 7.5‰), posterior middle frontal gyrus (pMFG; 6.0‰), middle middle frontal gyrus (mMFG; 5.9‰), ventral postcentral gyrus (vPoG; 5.8‰), and the anterior supramarginal gyrus (aSMG; 5.6‰). In contrast to that, the highest right-hemispheric error rates occurred after stimulation of the middle middle temporal gyrus (mMTG; 7.4‰), posterior superior temporal gyrus (pSTG; 6.7‰), dorsal precentral gyrus (dPrG; 6.5‰), and the anterior superior temporal gyrus (aSTG; 6.5‰).

Conclusions: Although error rates were low, the rTMS-based approach of investigating semantic processing during object naming shows convincing results compared to the current literature. Therefore, rTMS seems a valuable, safe, and reliable tool for the investigation of semantic processing within the healthy human brain.