Artikel
Does the SERPINA3 gene play a role in the formation of intracranial aneurysms?
Spielt das SERPINA3-Gen eine Rolle bei der Bildung intrakranieller Aneurysmen?
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Veröffentlicht: | 8. Mai 2006 |
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Gliederung
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Objective: The member 3 of clade A of serine proteinase inhibitors (SERPINA 3) regulates the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In previous studies, there was evidence that a polymorphism in the SERPINA3 gene was associated with intracranial aneurysms (IA) found in a Polish population as well as in cases of hemorrhagic stroke in Spanish patients. We performed a case/control study to determine whether this A/T polymorphism was associated with IA in Japanese patients.
Methods: 438 patients with intracranial aneurysms and 395 control cases of Japanese origin were genotyped for the SERPINA3 A/T polymorphism. By using a polymerase chain reaction and genotyping through direct sequencing in genomic DNA, we detected the SERPINA3 polymorphism.
Results: In 438 patients with intracranial aneurysms the SERPINA3 genotype distribution did not differ significantly from controls.
Conclusions: In the Japanese population, the A/T polymorphism of the SERPINA3 gene is not associated with intracranial aneurysms.