Artikel
The relationship between histopathological findings and 5-aminolevulinic acid induced fluorescence in glioma surgery
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Autoren
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Y. Kajimoto
- Department of Neurosurgery, Osaka Medical College, Osaka, Japan
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T. Masubuchi
- Department of Neurosurgery, Osaka Medical College, Osaka, Japan
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H. Tanaka
- Department of Neurosurgery, Osaka Medical College, Osaka, Japan
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M. Miyashita
- Department of Neurosurgery, Osaka Medical College, Osaka, Japan
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J. Aoki
- Department of Neurosurgery, Osaka Medical College, Osaka, Japan
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S.I. Miyatake
- Department of Neurosurgery, Osaka Medical College, Osaka, Japan
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T. Kuroiwa
- Department of Neurosurgery, Osaka Medical College, Osaka, Japan
| Veröffentlicht: | 8. Mai 2006 |
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Gliederung
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Objective: It is relative easy to remove the main mass of the malignant glioma, which shows strong fluorescence induced by 5-aminolevulinic acid (5-ALA). However, in order to remove the tumor maximally with preservation of neurological function, it is important to understand the implication of the fluorescence at the marginal zone of the tumor.
Methods: In this study, we characterized histopathological findings at the strong, vague fluorescent area in marginal zone (marginal vague) in four cases of glioblastoma.
Results: At the strong fluorescent area, the most of the cells were tumor cells and neuronal structures were destroyed. However, at the marginal vague fluorescent area, neuronal structures were almost preserved and tumor cell densities were less than 1/10 than that of the strong fluorescent area.
Conclusions: The vague fluorescence area, which is adjacent to the eloquent area, should not be removed so that neurologic function is preserved. On the other hand, the vague fluorescence area of the non-eloquent area should be extensively removed for tumor cell reduction.
