Artikel
Enhancement of the benefits of intraoperative electrophysiological recordings during framebased stereotactic surgeries by customized signal analysis
Verbesserte Nutzung elektrophysiologischer Ableitungen während rahmenbasierter stereotaktischer Eingriffe durch den Einsatz maßgefertigter Analysesoftware
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Autoren
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Kerstin Menne
- Institut für Signalverarbeitung und Prozessrechentechnik, Universität zu Lübeck, Seelandstr. 1a, 23569 Lübeck
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U. G. Hofmann
- Institut für Signalverarbeitung und Prozessrechentechnik, Universität zu Lübeck, Seelandstr. 1a, 23569 Lübeck
| Veröffentlicht: | 23. April 2004 |
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Gliederung
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Objective
We will present results of the BMBF project navEgate whose overall objective is the enhancement of target point accuracy during framebased stereotactic surgeries for the implantation of deep brain stimulators. At the Institute for Signalprocessing in Lübeck we especially focus on the development of online visualization and signal analysis tools that gain the utmost information from intraoperatively recorded electrophysiological signals.
Methods
The software is integrated into our 32-channel data acquisition system (50 kHz per channel), developed according to DIN EN 60601-1-4. The algorithms are tested on the basis of in situ recorded data from patients suffering from Parkinson Syndrome or Dystonia, kindly provided by some neurosurgeons, and on the basis of realistically simulated data. We chose features like wavelet coefficients, Fourier coefficients, correlations and spike rates to distinguish one brain region from the other. In addition, these features get stored related to an AC-PC based anatomical reference coordinate system in our database system navEbase. The complete navEgate system consists of the following components. A newly developed probe (IMM) enables synchronous recording from 32 channels, linearly or helically arranged on one shaft. The design allows to gain a neural signal depth profile from about the first 1 cm of probe length. The feed of the probe is controlled by a computerized microdrive (Thomas Recording). Preoperative planning and image-based navigation is performed within the new iPlan software (Brainlab). The penetration depth of the probe is there presented online on top of the patient image material.
Results
Our system is designed to assist novice as well as experienced neurosurgeons and to provide a great tool for medical research. The integrated database system enables the surgeon to compare current intraoperative data at a certain location against signal features to be expected at this point, thus providing additional feedback about the assumed position. Clinical trials of the complete system are expected for spring 2004.
