gms | German Medical Science

133. Kongress der Deutschen Gesellschaft für Chirurgie

Deutsche Gesellschaft für Chirurgie

26.04. - 29.04.2016, Berlin

Artikel

Artikel empfehlen

Proximal and distal loop duodeno-enterostomy shows a significant improvement of type 2 diabetes in obese Zucker rats 6 months after surgery

Meeting Abstract

Suche in Medline nach

  • Claudia Läßle - Universitätsklinikum Freiburg, Allgemein- und Viszeralchirurgie, Freiburg, Deutschland
  • Sven Michelmichel - Universitätsklinikum Freiburg, Allgemein- und Viszeralchirurgie, Freiburg, Deutschland
  • Gabriel Seifert - Universitätsklinikum Freiburg, Allgemein- und Viszeralchirurgie, Freiburg, Deutschland
  • Simon Küsters - Universitätsklinikum Freiburg, Allgemein- und Viszeralchirurgie, Freiburg, Deutschland
  • Ulrich Theodor Hopt - Universitätsklinikum Freiburg, Allgemein- und Viszeralchirurgie, Freiburg, Deutschland
  • Goran Marjanovic - Universitätsklinikum Freiburg, Allgemein- und Viszeralchirurgie, Freiburg, Deutschland
  • Jodok Matthias Fink - Universitätsklinikum Freiburg, Allgemein- und Viszeralchirurgie, Freiburg, Deutschland

Deutsche Gesellschaft für Chirurgie. 133. Kongress der Deutschen Gesellschaft für Chirurgie. Berlin, 26.-29.04.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. Doc16dgch534

doi: 10.3205/16dgch534, urn:nbn:de:0183-16dgch5344

Veröffentlicht: 21. April 2016

© 2016 Läßle et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Background: To evaluate which role increased ileal stimulation plays to gain an improvement of type 2 diabetes (TSDM), we performed a proximal and distal loop duodeno-enterostomy in obese Zucker rats.

Materials and methods: We made either a loop dudeno-jejunostomy (DJOS) with exclusion of 1/3 of total intestinal length, a loop duodeno-ileostomy (DiOS, exclusion of 2/3) or a SHAM operation on 8 week-old male obese diabetic Zucker rats. Each group includes 12 animals. 4, 12 and 24 weeks after surgery we performed an oral glucose tolerance test (OGTT) and monitored the increase of weight.

Results: Animals which received DJOS and DiOS procedures presented with significantly lower blood glucose levels already in the 4 weeks OGTT compared to SHAM animals (two-way ANOVA p<0.0001).

4 weeks after surgery, there was no significant difference between DJOS and DiOS animals. 12 weeks after surgery, the DJOS group showed significantly better blood glucose levels than the DiOS group (two-way ANOVA p=0,016) whereas after 24 weeks the results were reversed with better glucose values in the DiOS group (two-way ANOVA p=0,008). Compared to SHAM animals, DiOS and DJOS group presented with significantly improved glucose tolerance in two-way ANOVA and on individual time points at 12 and 24 weeks (two-way ANOVA p=<0.0001).

After an initially mainly parallel development, body weight gain after surgery was significantly greater in DIOS and DJOS animals when compared to SHAM.

At 24 weeks, body weight was equal in DIOS and DIOS groups (Mann-Whitney p=0.302).

Conclusion: This study shows that T2DM amelioration after loop duodeno-enterostomy is most likely caused by duodenal exclusion and somewhat questions the need for extensive hindgut stimulation.