gms | German Medical Science

133. Kongress der Deutschen Gesellschaft für Chirurgie

Deutsche Gesellschaft für Chirurgie

26.04. - 29.04.2016, Berlin

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Postoperative course of angiogenic cytokines after pancreatic cancer resection

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  • Cui Yang - Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie, Dresden, Deutschland
  • Nuh Rahbari - Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie, Dresden, Deutschland
  • Yakup Kulu - Universitätsklinikum Heidelberg, Allgemein-, Viszeral- & Transplantationschirurgie, Heidelberg, Deutschland
  • Moritz Koch - Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie, Dresden, Deutschland
  • Markus Wolfgang Büchler - Universitätsklinikum Heidelberg, Allgemein-, Viszeral- & Transplantationschirurgie, Heidelberg, Deutschland
  • Jürgen Weitz - Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie, Dresden, Deutschland
  • Christoph Reißfelder - Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie, Dresden, Deutschland

Deutsche Gesellschaft für Chirurgie. 133. Kongress der Deutschen Gesellschaft für Chirurgie. Berlin, 26.-29.04.2016. Düsseldorf: German Medical Science GMS Publishing House; 2016. Doc16dgch219

doi: 10.3205/16dgch219, urn:nbn:de:0183-16dgch2197

Veröffentlicht: 21. April 2016

© 2016 Yang et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Background: Circulating angiogenic cytokines have been researched as prognostic biomarkers and therapeutic targets in several solid tumors. However, their role as prognostic biomarkers in pancreatic cancer (PC) is unknown.

Materials and methods: Preoperative and postoparative blood samples were collected in patients undergoing curative resection of PC. Serum level of 13 angiogenic cytokines were analyzed using ELISA and Multiplex. The median Follow up was 17 months. 63 patients with PC and 12 patients with chronic pancreatitis (control group) were analyzed. Prognostic factors were identified by a Cox regression proportional hazard model.

Results: The study population included 37 males and 26 females with PC and a median age of 63 years. Differences between PC and the control group revealed for FGF (p=0.002), G-CSF (p=0.03) and TNFa (p=0.04). In the next step we could demonstrate that 26 out of 156 combinations of the cytokines interact significantly with each other. The most important analysis was the influence of postoperative changes of the cytokines on long term survival. A multivariate model showed that EGF (p=0.02), PDGFA-A (p=0.02), TNFa (p=0.001), VEGF (p=0.005) and IL 8 (p=0.049) were correlated with impaired survival.

Conclusion: This is the first study that compared 13 different angiogenic cytokines at the same time in a pre- und postoperative setting in PC patients. We were able to demonstrate that there are differences between PC und chronic pancreatitis. Furthermore, we could show that cytokines interact which each other, so the broad panel of 13 cytokines was essential. Finally, we could demonstrate that EGF, PDGFA-A, TNFa, VEGF and IL8 influenced long term survival. With this study we could evaluate new potential target parameters or biomarkers in PC patients that influence long term survival.