gms | German Medical Science

130. Kongress der Deutschen Gesellschaft für Chirurgie

Deutsche Gesellschaft für Chirurgie

30.04. - 03.05.2013, München

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A comparison of cardiac troponin I and creatine kinase-MB for selection of heart donors and as predictors of graft failure

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  • Assad Haneya - Universitätsklinikum Regensburg, Klinik für Herz- und Thoraxchirurgie, Regensburg
  • Alois Philipp - Universitätsklinikum Regensburg, Klinik für Herz- und Thoraxchirurgie, Regensburg
  • Alexander Fabricius - Universitätsklinikum Regensburg, Klinik für Herz- und Thoraxchirurgie, Regensburg
  • Philipp Kolat - Universitätsklinikum Regensburg, Klinik für Herz- und Thoraxchirurgie, Regensburg
  • Leopold Rupprecht - Universitätsklinikum Regensburg, Klinik für Herz- und Thoraxchirurgie, Regensburg
  • Stephan Hirt - Universitätsklinikum Regensburg, Klinik für Herz- und Thoraxchirurgie, Regensburg
  • Christof Schmid - Universitätsklinikum Regensburg, Klinik für Herz- und Thoraxchirurgie, Regensburg

Deutsche Gesellschaft für Chirurgie. 130. Kongress der Deutschen Gesellschaft für Chirurgie. München, 30.04.-03.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. Doc13dgch641

doi: 10.3205/13dgch641, urn:nbn:de:0183-13dgch6419

Veröffentlicht: 26. April 2013

© 2013 Haneya et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Introduction: Serum markers of myocardial cell injury are frequently measured in the evaluation of potential heart donors. The aim of this study was to evaluate cardiac troponin I (cTnI) and creatine kinase (CK)-MB as predictors of graft failure after heart transplantation (HTx).

Material and methods: cTnI and CK-MB serum concentrations were measured in samples collected immediately before pericardium opening from 131 consecutive brain-dead multiple-organ donors. The donors were retrospectively divided into 2 groups: group I (n=103) donors of graft with good function, group II (n=28) donors of graft with impaired function after HTx.

Results: No differences in donor and recipient demographic characteristics were found between both groups. There were no correlations between cTnI and CK-MB. The cTnI level was significantly higher in group I (0.60±0.85 ng/mL vs. 0.22±0.41 ng/mL; p=0.001). The CK-MB level was similar in both groups (23±24 U/L vs. 24±36 U/L; p=0.86). One or both markers were elevated in 45 donors (44%) in group I and in 21 donors (75%) in group II (p=0.005). CK-MB was elevated in 41 donors (40%) in group I and in 11 donors (40%) in group II (p=0.98). In contrast, cTnI was elevated in 33 donors (32%) in group I and in 18 donors (64%) in group II (p=0.004).

Conclusion: Elevated cTnI serum concentration in donors was independent prognostic marker of impaired graft function after HTx. cTnI is superior to CK-MB for the prediction of impending graft failure. Its use as additional parameter may improve heart donor selection.