Artikel
Gastric bypass surgery alters gut microbiota profile along the intestine
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Autoren
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Marco Bueter
- Universitätsspital Zürich, Klinik für Viszeral- und Transplantationschirurgie, Zürich
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Melania Osto
- Institut für Veterinärphysiologie, Vetsuisse-Fakultät Universität Zürich, Zürich
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Kathrin Abegg
- Institut für Veterinärphysiologie, Vetsuisse-Fakultät Universität Zürich, Zürich
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Marc Schiesser
- Universitätsspital Zürich, Klinik für Viszeral- und Transplantationschirurgie, Zürich
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Thomas A Lutz
- Institut für Veterinärphysiologie, Vetsuisse-Fakultät Universität Zürich, Zürich
| Veröffentlicht: | 26. April 2013 |
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Gliederung
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Introduction: Changes in fecal microbiota may be responsible for the metabolic changes observed after Roux-en-Y gastric bypass (RYGB) surgery. Altered nutrient flux after surgery might have different effects on the gut microbiota profile along the intestine. Here we assessed the bacterial composition in different corresponding intestinal segments after RYGB or sham surgery.
Material and methods: Fourteen weeks after RYGB or sham surgery, intestinal segments and contents were collected. Gut microbiota composition, intestinal preproglucagon, peptide YY (PYY) and cholecystokinin (CKK) expression and intestinal dipeptidyl peptidase-4 (DPP4) activity were measured.
Results: Total bacteria, Bifidobacteria, and Bacteroides-Prevotella spp content were significantly increased in the alimentary limb and common channel of RYGB rats compared to sham rats. RYGB rats also had higher Bifidobacteria and Bacteroides-Prevotella spp in colon, and Bifidobacteria and Lactobacillus in caecum. Preproglucagon, PYY and CKK expression were increased in the alimentary limb and common channel of RYGB rats, DPP4 activity was unchanged.
Conclusion: In conclusion, RYGB surgery leads to major changes in the microbiota of the alimentary limb and the common channel. This may be related to altered production of gastrointestinal hormones known to regulate energy balance. This suggests that postsurgical changes in intestinal segments may significantly contribute to the beneficial metabolic effects of RYGB surgery.
