Artikel
Iodine deficiency and quality of life – a systematic review of health-state utilities in iodine deficiency disorders
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Autoren
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V. Qerimi
- UMIT - University for Health Sciences, Medical Informatics and Technology, Institute for Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, Hall, Österreich; Faculty of Pharmacy, School of PhD Studies, Ss. Cyril and Methodius University, Skopje, Mazedonien
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M. Schaffner
- UMIT - University for Health Sciences, Medical Informatics and Technology, Institute for Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, Hall, Österreich
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S. Puntscher
- UMIT - University for Health Sciences, Medical Informatics and Technology, Institute for Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, Hall, Österreich
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A. Conrads-Frank
- UMIT - University for Health Sciences, Medical Informatics and Technology, Institute for Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, Hall, Österreich
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U. Siebert
- UMIT - University for Health Sciences, Medical Informatics and Technology, Institute for Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, Hall, Österreich; Center for Health Decision Science, Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Institute for Technology Assessment and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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U. Rochau
- UMIT - University for Health Sciences, Medical Informatics and Technology, Institute for Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, Hall, Österreich
| Veröffentlicht: | 10. September 2018 |
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Gliederung
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Background: Iodine deficiency can cause a variety of diseases collectively termed iodine deficiency disorders (IDDs). IDDs negatively affect quality-of life. Health-related quality-of life can be expressed as health-state utility (HSU). HSUs are estimates of a preference for a given state of health on a scale from 0-1. A value of 1 represents full health, 0 represents death.
Question: Which HSU values can be derived from the literature for diseases or health conditions associated with iodine deficiency?
Methods: We conducted a comprehensive systematic literature review in PubMed/MEDLINE, Tufts CEA Registry, NHS EED and Cochrane to identify studies that reported HSUs for several health states associated with iodine deficiency. Evidence tables were created to systematically summarize the extracted HSUs.
Results: After title/abstract and full-text screening, 43 studies were included. The HSUs were derived with different measures (SF-36, SF-6D, EQ-5D, time-trade-off questionnaires, standard gamble, Health-Utility Index, expert estimates). For goiter and thyroid nodules, HSUs were estimated between 0.95 (after thyroidectomy) and 0.98 (without treatment). HSUs for hypothyroidism ranged from 0.95 (no treatment) to 1 (treated subclinical hypothyroidism). For hyperthyroidism, HSUs between 0.47 (no treatment) and 0.98 (with anti-thyroid medication) were reported. HSUs for congenital hypothyroidism ranged from 0.47 (without screening) to 0.9 (with screening).
Discussion: Various HSUs were identified for health states associated with IDDs. To be able to determine the appropriate HSUs for the respective health state, the populations and stage of disease should be taken into account.
Take Home Message for the Practice: The identified HSUs can be used in decision-analytic modeling to assess the benefit-harm ratio of IDD prevention programs.
