Artikel
Pre-clinical cortical prosthesis studies at ReVision Implant
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Autoren
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Laurens Goyvaerts
- Micro- and Nanosystems, Dept. of Electrical Engineering, KU Leuven, Belgium; ReVision Implant, Belgium
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M. Schelles
- Micro- and Nanosystems, Dept. of Electrical Engineering, KU Leuven, Belgium; ReVision Implant, Belgium
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L. Merken
- ReVision Implant, Belgium; Laboratory for Neuro- and Psychophysiology, Dept. of Neuroscience, KU Leuven, Belgium
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P. Janssen
- Laboratory for Neuro- and Psychophysiology, Dept. of Neuroscience, KU Leuven, Belgium
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M. Kraft
- Micro- and Nanosystems, Dept. of Electrical Engineering, KU Leuven, Belgium
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F. Ceyssens
- ReVision Implant, Belgium
| Veröffentlicht: | 9. Mai 2025 |
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Gliederung
Text
Objective: To test different properties of ReVision's flexible intracortical electrodes and visual prosthesis: functionality, long-term biocompatibility, and behavioural effects.
Materials and Methods: We applied intracortical stimulation with flexible electrode arrays to the visual cortex of three different types of animals. We studied the response to current steering in transgenic mice under two-photon calcium imaging, the stability of the electrodes and histology of insertion sites in sheep, and the behavioural outcome to elicited phosphenes in non-human primates.
Results: Advanced stimulation patterns such as current steering have been shown to increase the selectivity, and therefore resolution of a visual prosthesis, with a factor of around 5. Chronic stimulation studies have provided evidence for the high biocompatibility of our insertion techniques, electrode arrays, and stimulation patterns. Intracortical stimulation in the non-human primate visual cortex with our intracortical electrodes could elicit phosphenes.
Discussion: These results will form the basis for future first-in-human tests.
Acknowledgement: This work was supported by VLAIO (HBC.2021.0187) and the HORIZON EIC Pathfinder Grant (No101071015).
