gms | German Medical Science

Artificial Vision 2024

The International Symposium on Visual Prosthetics

05. - 06.12.2024, Aachen, Germany

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Distribution of neurotransmitters in a retinitis pigmentosa rodent model

Meeting Abstract

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  • Mari Bonse - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich
  • J. Wang - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich
  • S. Krause - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich
  • M. Schöneck - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich
  • N. Burda - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich
  • M. Cremer - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich
  • N. Jon Shah - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich; JARA BRAIN, Institute for Neuroscience and Medicine, Forschungszentrum Jülich; Department of Neurology, RWTH Aachen University
  • K.-J. Langen - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich; Department of Nuclear Medicine, RWTH University Hospital
  • B. Kampa - Department of Neurophysiology, Institute for Biology II, RWTH Aachen University; JARA BRAIN, Institute for Neuroscience and Medicine, Forschungszentrum Jülich
  • F. Müller - Institute of Biological Information Processing (IBI-1), Forschungszentrum Jülich
  • A. Willuweit - Institute of Neuroscience and Medicine (INM-4, INM-2, INM-11), Forschungszentrum Jülich

Artificial Vision 2024. Aachen, 05.-06.12.2024. Düsseldorf: German Medical Science GMS Publishing House; 2025. Doc24artvis04

doi: 10.3205/24artvis04, urn:nbn:de:0183-24artvis048

Veröffentlicht: 9. Mai 2025

© 2025 Bonse et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

Gliederung

Text

Objective: Degeneration of the retina is one of the main causes of vision loss. Promising treatments are retinal prostheses. However, a thorough understanding of the visual system and its changes during retinal degeneration is mandatory in the development of visual prostheses. In this study, we aim to assess the distribution of different neurotransmitters involved in the visual pathways.

Materials and Methods: Royal College of Surgeons (RCS) rats, a retinitis pigmentosa model, were used for neurotransmitter receptor analysis by ex vivo autoradiography with Muscimol (GABA-A-receptor) and 8-OH-DPAT (5-HT1A-receptor). RCS rats of different ages (P30 (30 days), P50, P70 and P90) were compared to age matched non-dystrophic congenic pigmented rats.

Results: Binding of Muscimol was constantly decreasing in both groups from age P30 to P70 in all brain regions analyzed, with a tendency of lower binding in RCS brain. However, DPAT binding was rather stable over time and in both groups.

Discussion: Densities of GABA-A and 5-HT1A receptors showed no major differences but a trend towards reduced GABA-A receptor levels in RCS rats. Other neurotransmitter receptors will be investigated to confirm this finding.

Acknowledgment: This work is supported by RTG 2610, DFG.