Artikel
Short phases of pathological rhythmic activity similar to RD retinae are also present in retinae of RCS rats
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Autoren
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Nruthyathi Nruthyathi
- Institute of Biological Information Processing, Molecular and Cellular Physiology (IBI-1), Forschungszentrum Jülich
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M. Jung
- Institute of Biological Information Processing, Bioelectronics (IBI-3), Forschungszentrum Jülich
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J. Wang
- Institute of Neuroscience and Medicine (INM-4), Forschungszentrum Jülich
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V.R. Montes
- Institute of Biological Information Processing, Bioelectronics (IBI-3), Forschungszentrum Jülich
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A. Offenhäusser
- Institute of Biological Information Processing, Bioelectronics (IBI-3), Forschungszentrum Jülich
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A. Willuweit
- Institute of Neuroscience and Medicine (INM-4), Forschungszentrum Jülich
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F. Müller
- Institute of Biological Information Processing, Molecular and Cellular Physiology (IBI-1), Forschungszentrum Jülich
| Veröffentlicht: | 9. Mai 2025 |
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Gliederung
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Objective: Retinitis pigmentosa (RP) is a leading cause of blindness. Several rodent models mimicking retinal changes of RP in humans are used, among them the rd1 and rd10 mouse and the RCS rat. In many models, a pathological rhythmic activity as well as lowered efficiency of electrical stimulation were observed. In rd10 retina, both events were shown to be intimately linked. Surprisingly, to our knowledge no retinal oscillations have been reported in RCS retina. As oscillations might reduce the performance of a retinal implant, it is important to know, whether they are a common feature of retinal degeneration models.
Materials and Methods: Electrical activity was recorded in retinae of 3–19 month (M3–19) old RCS rats in vitro.
Results: Short events resembling oscillations in rd retinae were observed in M3 RCS retinae. Oscillations occurred more often and were more pronounced the older the animals were. Yet, even at M18–19 oscillatory phases were short and separated by long phases of non-oscillatory activity.
Discussion: In advanced stages of degeneration, RCS retinae display oscillations similar to rd retinae. Oscillatory phases are shorter than in rd retinae and may, therefore, have escaped detection in earlier studies. These results together with results observed in non-rodent models suggest that pathological rhythmic activity is a common feature in RP models.
Acknowledgment: This work is supported by RTG 2610, DFG - Deutsche Forschungsgemeinschaft.
