Artikel
Corneal recordings reveals periodic rhythmic activity in-vivo
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Autoren
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David G. Litvin
- Ophthalmic and Neural Technologies Laboratory, Department of Ophthalmology, University of Lausanne, Hôpital Ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland
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A. Boizot
- Ophthalmic and Neural Technologies Laboratory, Department of Ophthalmology, University of Lausanne, Hôpital Ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland
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D. Ghezzi
- Ophthalmic and Neural Technologies Laboratory, Department of Ophthalmology, University of Lausanne, Hôpital Ophtalmique Jules-Gonin, Fondation Asile des Aveugles, Lausanne, Switzerland
| Veröffentlicht: | 9. Mai 2025 |
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Gliederung
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Objective: To measure in-vivo the periodic bursting activity of retinal ganglion cells following retinal degeneration in rd1 mice.
Materials and Methods: We recorded retinal activity using a contact lens electrode. Spontaneous activity was processed to obtain the power spectral density of the signal to reveal dominant peaks corresponding to periodic bursting activity of retinal ganglion cells.
Results: Periodic bursting activity of retinal ganglion cells (at 10–15 Hz) was detected in all recorded animals. Chronic recordings from postnatal week 4 showed that periodic bursting activity developed over weeks and stabilises at postnatal week 6.
Discussion: We propose a novel noninvasive method to monitor alterations to spontaneous retinal activity in-vivo.
Acknowledgment: This work was supported by the Fondation E. Gelbert, the Novartis foundation for medical-biological research, and the fondation asile des aveugles.
