Artikel
A suprachoroidal retinal prosthesis: initial functional results
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Autoren
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Penelope J. Allen
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; Department of Surgery (Ophthalmology), University of Melbourne/AUS
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D. A. X. Nayagam
- Bionics Institute, Melbourne/AUS; Medical Bionics Department, University of Melbourne/AUS
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C. D. Luu
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; Department of Surgery (Ophthalmology), University of Melbourne/AUS
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N. Barnes
- Data 61, Commonwealth Scientific and Industrial Research Organisation, Canberra/AUS; The Australian National University, Canberra/AUS
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M. Kolic
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
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K. Young
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
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E. K. Baglin
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
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C. J. Abbott
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; Department of Surgery (Ophthalmology), University of Melbourne/AUS
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R. J. Briggs
- Otolaryngology, University of Melbourne/AUS
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J. Yeoh
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
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W. G. Kentler
- School of Engineering, University of Melbourne/AUS
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J. Kvansakul
- Bionics Institute, Melbourne/AUS
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S. A. Titchener
- Bionics Institute, Melbourne/AUS
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M. A. Petoe
- Bionics Institute, Melbourne/AUS; Medical Bionics Department, University of Melbourne/AUS
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C. E. Williams
- Bionics Institute, Melbourne/AUS; Medical Bionics Department, University of Melbourne/AUS
| Veröffentlicht: | 10. Dezember 2019 |
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Gliederung
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Objective: The success of our prototype clinical trial (NCT01603576) of a suprachoroidal retinal prosthesis led us to develop a second generation fully implantable device, with the aim of providing visual information to profoundly visually impaired patients (NCT03406416). We believe that enabling the patients to use the device outside of the laboratory will enhance its functionality. We are comparing the performance of orientation and mobility (OM) and activities of daily living (ADL) tasks pre-implant and post activation of the device.
Materials and methods: The second generation suprachoroidal retinal prosthesis was successfully implanted unilaterally in four participants with advanced RP during 2018. The 44 channel (44Ch) electrode array is connected to a subcutaneous receiver stimulator. After a period of vision rehabilitation training, participants were assessed on three tasks; table-top search (TTS), doorway detection (DWD) and obstacle avoidance (OA), comparing performance between device on and device off. Assessment time points were; prior to implantation (baseline, BL) and post device activation, Week 17, Week 20 and ongoing at 12 week intervals.
Results: All four patients perform better for all tasks with device on compared to device off. For TTS, naming location of objects is good but identification of the object is more difficult. DWD performance is excellent with touch distance significantly reduced for all patients. Assessment of OA in the corridor obstacle course reveals that object detection is excellent but avoidance is moderate.
Discussion: The initial results for the 44Ch suprachoroidal retinal prosthesis indicate that the device has the capability to improve functional vision for people with profound vision loss from RP. Further training and familiarisation of visual input generated by the device could improve performance with the device and we continue to collect this data.
