gms | German Medical Science

Artificial Vision 2019

The International Symposium on Visual Prosthetics

13.12. - 14.12.2019, Aachen

Development of reliable hybrid packaging technology for sub-retinal stimulation system

Meeting Abstract

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  • Young-jin Kim - Osong Medical Innovation Foundation/ROK
  • H. Jung - Osong Medical Innovation Foundation/ROK
  • S.-A Lee - Osong Medical Innovation Foundation/ROK

Artificial Vision 2019. Aachen, 13.-14.12.2019. Düsseldorf: German Medical Science GMS Publishing House; 2019. Doc19artvis13

doi: 10.3205/19artvis13, urn:nbn:de:0183-19artvis139

Veröffentlicht: 10. Dezember 2019

© 2019 Kim et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe



Objective: Biocompatible and long-term reliable packaging are essential for implantable device packaging. To reach the goal, various materials and processes are developed in many research. In this research, we propose new hybrid packaging technology that can secure as noted above characteristics for implantable devices especially in the sub-retinal stimulation system.

Materials and methods: Medical grade silicone elastomer, epoxy and parylene C were used as hybrid packaging materials. We developed single and hybrid coating process and improve process for better adhesion with different materials. Also each samples were evaluated light transmission, moisture permeability, biocompatibility and machine safety test in real and accelerated environments.

Results: In case of single coating, each materials show good biocompatibility (≥ 80% cell viability), light transmittance (≥ 80% at 550 nm) and moisture permeability (≤1.578417 g/m2∙day). In the results of hybrid coating, characteristic of light transmittance was lower but moisture permeability was improved by additional layer and biocompatibility was decided by the outermost material.

Discussion: In this study, we evaluate fundamental characteristics each coating process. To apply sub-retinal stimulation system, we need to develop customizing process for 4 parts (sensor and stimulator, cable, circuits and connecting). Also additional long-term reliability test by moisture permeability test in accelerated environment and implant test in animals are needed.

Acknowledgment: This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (Ministry of Science, ICT) (No. 2019M3A9E2030769).