Artikel
“Quiescent” CNV in AMD – characteristics and consequences
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Autoren
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Giuseppe Querques
- Milan/I; Creteil/F
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R. Sacconi
- Milan/I
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V. Capuano
- Creteil/F
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A. Carnevali
- Milan/I; Catanzaro/I
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D. Colantuono
- Creteil/F
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M. Battista
- Milan/I
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E. Borrelli
- Milan/I
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A. Miere
- Creteil/F
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M. Parravano
- Foundation G.B. Bietti-IRCCS, Rome/I
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E. Costanzo
- Foundation G.B. Bietti-IRCCS, Rome/I
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L. Querques
- Milan/I
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E.H. Souied
- Creteil/F
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F. Bandello
- Milan/I
| Veröffentlicht: | 5. Februar 2020 |
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Gliederung
Text
Purpose: To analyze different clinical and anatomical features in treatment-naïve non-exudative macular neovascularizations (MNVs) secondary to age-related macular disease (AMD).
Methods: In this longitudinal study with a minimum follow-up of 1 year, consecutive AMD patients with treatment-naïve non-exudative MNV were enrolled. Patients were divided in: short-term activated MNV group (exudation before 6-month) and quiescent MNV group (per definition no exudation during a minimum 6-month follow-up) showing no or late activation during follow-up (persistently quiescent and long-term activated quiescent MNV group, respectively). MNV growth rate and changes in quantitative optical coherence tomography angiography (OCT-A) features during the follow-up were analyzed between different subgroups.
Results: Thirty-one eyes (28 patients, mean age 75±9 years) were included. During the follow-up (mean duration: 22±9 months) 4 eyes (13%) showed exudation before 6-month follow-up (short-term activated MNV group), whereas 21 eyes (68%) did not develop signs of exudation (persistently quiescent group), and 6 eyes (19%) developed exudation after the minimum 6-month follow-up (long-term activated quiescent MNV group). Monthly MNV growth rate was significantly higher in the short-term activated MNV group (growth rate of 13.30%/month), vs persistently quiescent MNV group (0.64%/month, p<0.001) and long-term activated quiescent MNV group (1.07%/month, p<0.001). Furthermore, at the baseline, PD of short-term activated MNV group was significantly greater in comparison to persistently quiescent MNV group (p=0.001) and long-term activated quiescent MNV group (p=0.106).
Conclusions: We reported two different patterns for subclinical MNVs: subclinical MNVs characterized by short-term activation which could represent simply a pre-exudative stage in the development of an ordinary type 1 MNV, and quiescent MNVs characterized by low rate of growth and possible long-term activation. Analysis of OCT-A features may predict short-term activation for subclinical MNV.
