gms | German Medical Science

7th International Symposium on AMD: Age-related Macular Degeneration – Understanding Pathogenetic Mechanisms of Disease

20.09. - 21.09.2019, Baden-Baden

Neuroprotection as a therapeutic option for GA

Meeting Abstract

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  • Victor Chong - Boehringer Ingelheim International GmBH, Ingelheim/D

7th International Symposium on AMD: Age-related Macular Degeneration - Understanding Pathogenetic Mechanisms of Disease. Baden-Baden, 20.-21.09.2019. Düsseldorf: German Medical Science GMS Publishing House; 2020. Doc19amd54

doi: 10.3205/19amd54, urn:nbn:de:0183-19amd549

Veröffentlicht: 5. Februar 2020

© 2020 Chong.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Background: Geographic atrophy (GA) is the leading cause of legal blindness in the developed nations with no approved treatment. The current therapeutic focus is on the complement pathway despite several failure.

Methods: Literature review and expert opinion.

Results: Neuroprotection, including photoreceptor protection, can be a therapeutic option for GA. There are extensive pre-clinical to support multiple agents can protect photoreceptor loss in various animal models. There are Phase 2 clinical trial data to support even with photoreceptor protection can slow RPE loss as shown in AF imaging.

Conclusion: It is unclear whether a sub-group of GA might benefit most from neuroprotection.