Artikel
Choriocapillaris imaging using SS-OCT angiography in AMD
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Autoren
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Philip J. Rosenfeld
- Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
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Marie Thulliez
- Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
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Qinqin Zhang
- Departments of Bioengineering and Ophthalmology, Seattle, Washington
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Yingying Shi
- Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
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Hao Zhou
- Departments of Bioengineering and Ophthalmology, Seattle, Washington
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Zhongdi Chu
- Departments of Bioengineering and Ophthalmology, Seattle, Washington
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Cancan Lyu
- Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
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Luis de Sisternes
- Research and Development, Carl Zeiss Meditec, Inc., Dublin, CA
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Mary K. Durbin
- Research and Development, Carl Zeiss Meditec, Inc., Dublin, CA
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William Feuer
- Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
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Giovanni Gregori
- Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
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Ruikang K. Wang
- Departments of Bioengineering and Ophthalmology, Seattle, Washington
| Veröffentlicht: | 5. Februar 2020 |
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Gliederung
Text
Purpose: Imaging of the choriocapillaris (CC) and choroid were performed using swept source optical coherence tomography angiography (SS-OCTA) in eyes with age-related macular degeneration (AMD). Our initial studies involved AMD eyes with geographic atrophy (GA), also known as complete retinal pigment epithelium (RPE) and outer retinal atrophy (cRORA). The associations between enlargement rates (ERs) of GA and the measurements of CC perfusion, choroidal thicknesses, and choroidal vessel vascular densities (CVVDs) were investigated.
Methods: Patients with non-exudative AMD were imaged using a 100-kHz SS-OCT instrument (PLEX Elite 9000, Carl Zeiss Meditec). Both 6x6 mm and 12X12 mm scan patterns were performed. GA area measurements were obtained from en face SS-OCT sub-RPE slab images. Visualization of the CC and quantification of flow impairment were performed using SS-OCT angiography (SS-OCTA). The percentage of CC flow deficits (FD%), the average FD area measurements, the choroidal thickness (CT) measurements, and the CVVDs were calculated in regions surrounding the GA.
Results: In 32 eyes, the annual square root ERs for GA ranged from 0.07 to 0.75 mm/year. The highest FD values were found in the region closest to the margin of GA. However, the strongest correlation was found between the ERs and average CC FD area measurements away from the margin of GA and calculated from the total scan area minus the area of GA (p<0.001). While CT measurements and CVVDs were decreased in AMD eyes with GA, the CC impairment correlated best with the ER of GA
Conclusions: Contrary to expectations, the strongest correlations between the ER of GA and CC FDs were found when the entire scan area minus the area of GA was used rather than the region immediately around the GA. The observation that CC flow impairment, a thinner choroid, and a decreased CVVD exist in AMD eyes with GA strongly suggest that choroidal perfusion plays an important role in AMD progression and growth of GA.
