Artikel
Correlations in mulitmodal macular pigment measurements and fluorescence lifetime imaging opthalmoscopy in AMD
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Autoren
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Damian Jaggi
- Bern/CH
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Y. Solberg
- Bern/CH
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C. Dysli
- Bern/CH
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S. Wolf
- Bern/CH
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M. Zinkernagel
- Bern/CH
| Veröffentlicht: | 5. Februar 2020 |
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Gliederung
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Background: Purpose of this study was to compare two macular pigment optical density (MPOD) imaging modalities with fluorescence lifetime imaging ophthalmoscopy (FLIO) in patients with nonexsudative age-related macular degeneration (AMD).
Methods: Twenty patients with nonexsudative AMD were included in this study. Macular pigment optical density (MPOD) was measured using dual wavelength retinal autofluorescence imaging (AFI) and heterochromatic flicker photometry (HFP). Retinal autofluorescence lifetimes were measured using FLIO (Heidelberg Engineering, Germany) and analyzed in two spectral channels (SSC; 498 to 560 nm, LSC; 560 to 720 nm). Statistical analysis was performed with Pearson correlations.
Results: AFI and HFP strongly correlated at 0.5 degree of eccentricity (r2=0.83, p<0.0001). Weaker but significant correlations were observed at 2 and 9 degree (r2=0.68, p<0.0001 and r2=0.46, p<0.0001). FLIO correlated with both AFI (SSC; r2=0.57, p<0.0001) and HFP (SSC; r2=0.39, p=0.003).
Conclusions: In addition to the well-established AFI, HFP and FLIO seem to be decent Methods to investigate macular pigment in AMD. We confirm the previously described inverse correlation between FLIO and MPOD measurements.
