gms | German Medical Science

7th International Symposium on AMD: Age-related Macular Degeneration – Understanding Pathogenetic Mechanisms of Disease

20.09. - 21.09.2019, Baden-Baden

Microglia as important part of the retina: Its role in AMD

Meeting Abstract

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  • Thomas Langmann - Köln/D
  • A. Wolf - Köln/D

7th International Symposium on AMD: Age-related Macular Degeneration - Understanding Pathogenetic Mechanisms of Disease. Baden-Baden, 20.-21.09.2019. Düsseldorf: German Medical Science GMS Publishing House; 2020. Doc19amd19

doi: 10.3205/19amd19, urn:nbn:de:0183-19amd195

Veröffentlicht: 5. Februar 2020

© 2020 Langmann et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

This talk highlights the role of key immune pathways in the pathophysiology of major retinal degenerative diseases including age-related macular degeneration. We will first discuss the mechanisms how loss of retinal homeostasis evokes an unbalanced immune reaction involving responses of local microglia and recruited macrophages. Presenting these innate immune cells as targets, we specifically emphasize the concept of immunomodulation as potential treatment strategy to prevent or delay vision loss. Promising molecules are ligands for phagocyte receptors, intracellular regulators involved in the activation of microglia and more general modifiers of their inflammatory response and migration. We briefly summarize the scientific evidence for this strategy from preclinical animal models, human ocular tissue analyses, and clinical trials evolving in the last few years.