gms | German Medical Science

7th International Symposium on AMD: Age-related Macular Degeneration – Understanding Pathogenetic Mechanisms of Disease

20.09. - 21.09.2019, Baden-Baden

Associations of the intestinal microbiome with AMD

Meeting Abstract

  • Martin Zinkernagel - Bern/CH; Department for BioMedical Research, University of Bern/CH
  • D. Zysset - Department for BioMedical Research, University of Bern/CH
  • I. Keller - Swiss Institute of Bioinformatics, Bern/CH
  • L. Berger - Bern/CH
  • B. Yilmaz - Department for BioMedical Research, University of Bern/CH
  • S. Wolf - Bern/CH

7th International Symposium on AMD: Age-related Macular Degeneration - Understanding Pathogenetic Mechanisms of Disease. Baden-Baden, 20.-21.09.2019. Düsseldorf: German Medical Science GMS Publishing House; 2020. Doc19amd13

doi: 10.3205/19amd13, urn:nbn:de:0183-19amd131

Veröffentlicht: 5. Februar 2020

© 2020 Zinkernagel et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Background: Recent evidence has shown that the gut microbiom, directly or indirectly through its components, is associated with age related macular degeneration.

Methods: The gut microbiome of 57 patients with age related macular degeneration and 58 healthc age and sex matched controls was sequenced using the Illumina HiSeq 3000 platform. All participants were subjected to an ophthalmic examination including optical coherence tomography and standard fundus color photography.

Results: Several taxonomic features of the intestinal microbiome that differ between patients and healthy controls were identified: The genus Oscillibacter and Bacteroides species were found to be enriched in healthy controls relative to AMD patients. In contrast, the phyla Firmicutes was enriched in AMD patients compared to controls.

Conclusion: This data confirms earlier findings that the composition of the gut microbiome is associated with age related macular degeneration. Whether this effect is mediated via alterations in metabolite uptake or via microbiota-cytokine interactions remains to be investigated.