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7th International Symposium on AMD: Age-related Macular Degeneration – Understanding Pathogenetic Mechanisms of Disease

20.09. - 21.09.2019, Baden-Baden

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EyeRisk study – risk factors for AMD phenotypes and progression?

Meeting Abstract

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  • Magda A. Meester-Smoor - Rotterdam/NL
  • C.C.W. Klaver - Rotterdam/NL

7th International Symposium on AMD: Age-related Macular Degeneration - Understanding Pathogenetic Mechanisms of Disease. Baden-Baden, 20.-21.09.2019. Düsseldorf: German Medical Science GMS Publishing House; 2020. Doc19amd08

doi: 10.3205/19amd08, urn:nbn:de:0183-19amd089

Veröffentlicht: 5. Februar 2020

© 2020 Meester-Smoor et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.

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The H2020 funded EYE-RISK project aimed to identify frequency and morbidity of AMD in Europe, and to specify who is at risk of developing AMD, who is at risk for progression, why and how risks combine to advance progression, and what we can do to lower the risk.

Existing epidemiologic data from >45,000 individuals aged 40+ from ten countries in Europe were harmonized and entered into a common database. Prevalence, visual decline, genetic and non-genetic risk factors were investigated and analysed for geographic differences and time trends.

We found that AMD will become an even more significant health problem in Europe in the near future and that long term visual function of AMD continues to be poor. Furthermore, we showed that genetic testing combined with environmental factors for AMD can be very predictive and that lipids are implicated in AMD with a surprising direction of effect.