gms | German Medical Science

VI. International Symposium on AMD – Age-Related Macular Degeneration – Emerging Concepts – Exploring known and Identifying new Pathways

11. - 12.09.2015, Baden-Baden

Exudative AMD in OCT-angiography – correlation of classic and occult CNV in fluorescein angiography and OCT-angiography

Meeting Abstract

  • Marie-Louise Farecki - Münster
  • M. Ziegler - Münster
  • B. Heimes - Münster
  • M. Gutfleisch - Münster
  • G. Spital - Münster
  • A. Lommatzsch - Münster
  • D. Pauleikhoff - Münster

VI. International Symposium on AMD – Age-Related Macular Degeneration – Emerging Concepts – Exploring known and Identifying new Pathways. Baden-Baden, 11.-12.09.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. Doc15amd36

doi: 10.3205/15amd36, urn:nbn:de:0183-15amd367

Veröffentlicht: 1. Oktober 2015

© 2015 Farecki et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Background: OCT-angiography (phase-variant-OCT) is a new method to visualize retinal and choroidal circulation within seconds with a miotic pupil and without the need of dye injection. Aim of this study was to compare and analyze the results of deep retinal layers and superficial choroidal layers in classic and occult CNV due to exudative AMD.

Patients and methods: We categorized 15 CNV in patients with exudative AMD by fluorescein angiography: 5 predominantly classic CNV, 5 minimally classic, 5 occult CNV. The vascular structure in OCT-angiography (Angiovue, Optovue, Fremont CA, USA) has been analyzed in the area of classic and occult CNV. In this connection the medium choroid, choriocapillaris, RPE and deep retinal layers have been described systematically in 20 micron layers. The different CNV-sections characterized by fluorescein angiography were examined by their ability to clearly distinguish from surrounding circulation, vascular fill and dimension.

Results: In all CNV lesions the new vessels were seen in OCT-angiography in different layers. In classic CNV there was a better presentation, higher flow and a distinctive demarcation of the deep retinal layers whereas occult CNV were harder to separate and showed a flat expansiveness with less flow. Occult CNV were in contrast to classic CNV not seen in the outer retina. The dimension of classic and occult CNV were better visible than in fluorescein angiography but corresponded in dimension.

Conclusion: OCT-angiography is able to define and show CNV due to exudative AMD characterized by fluorescein angiography. However, an explicit analysis algorithm has to be defined which describes altered vascular layers and observes vascular changes in this area for different CNV phenotypes.