gms | German Medical Science

VI. International Symposium on AMD – Age-Related Macular Degeneration – Emerging Concepts – Exploring known and Identifying new Pathways

11. - 12.09.2015, Baden-Baden

Inner nuclear layer thickening in patients with geographic atrophy

Meeting Abstract

  • Martin Zinkernagel - Bern
  • D. Jaggi - Bern
  • S. Wolf - Bern
  • L. Berger - Bern
  • A. Ebneter - Bern

VI. International Symposium on AMD – Age-Related Macular Degeneration – Emerging Concepts – Exploring known and Identifying new Pathways. Baden-Baden, 11.-12.09.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. Doc15amd33

doi: 10.3205/15amd33, urn:nbn:de:0183-15amd339

Veröffentlicht: 1. Oktober 2015

© 2015 Zinkernagel et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Purpose: The aim of this study was to identify and quantify thickness changes in the inner retina in patients with geographic atrophy (GA).

Methods: Patients with GA were assessed annually using combined near infrared reflectance (NIR) and high-resolution spectral domain optical coherence tomography (SD-OCT). Horizontal cross-hair scans were segmented using the commercial program Heidelberg Eye Explorer. Average layer thicknesses (ALTs) were measured using the software ImageJ. The area of GA was compared to an adjacent temporal zone without RPE atrophy. The longitudinal changes of the ALT in the area of GA were analyzed.

Results: 29 eyes of 29 patients were included in this study. In areas with GA the INL thickness increased significantly (P<0.0001) compared to the adjacent temporal zone. No significant change of INL thickness over time was detected.

Conclusion: The increase of INL thickness in patients with GA is a new finding and might be used as a valuable prediction factor for GA progression rate.