Artikel
Correlation of outer nuclear layer thickness with scotopic and photopic fundus-controlled perimetry in patients with reticular drusen
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Autoren
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Julia S. Steinberg
- Bonn
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M. Fleckenstein
- Bonn
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R. Fimmers
- Bonn
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F. G. Holz
- Bonn
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S. Schmitz-Valckenberg
- Bonn
| Veröffentlicht: | 1. Oktober 2015 |
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Gliederung
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Background: To correlate outer nuclear layer (ONL) thickness with scotopic and photopic fundus-controlled perimetry in patients with reticular drusen (RDR) and age-related macular degeneration.
Methods: Using multimodal retinal imaging (color fundus photography, confocal scanning laser ophthalmoscopy: near-infrared, fundus autofluorescence, multicolor and spectral-domain optical coherence tomography raster scan (30°x25°, 61 B-scans), retinal areas with RDR (category 1) and no visible pathological alterations (category 2) were identified in 20 eyes from 17 patients (mean age 75.8 years, range 62-87). Scotopic (Goldmann V, 200msec, 4-2 strategy) and photopic (Goldmann III, 200msec, 4-2 strategy) fundus-controlled perimetry (MP1S, Nidek Technologies, Padova, Italy) was performed using a grid with 56 stimulus points. After manual correction of the automatic segmentation of the ONL, the thickness values were spatially correlated to respective scotopic and photopic sensitivities.
Results: The mean ONL thickness was 67.4µm ± 5.6µm (range 56-77) for category 1 (mean number of stimulus points/eye: 33.5 (range 7-49)) and 74.6µm ± 5.9µm (range 58-86) for category 2 (mean number of stimulus points/eye: 20.2 (range 6-37)) (p<0.001). The mean scotopic sensitivity was 13.1 dB ± 3.1 (range 9-18) for category 1 and 18.2 dB ± 2,2 (range 13-20) for category 2 (p<0.001). The analysis of the photopic sensitivity revealed a mean sensitivity of 17.3 dB ± 2.6 (range 9-20) for category 1 and 18.6 dB ± 2.4 (range 10-20) for category 2 (p=0.03). Overall there was a trend towards an increase in ONL thickness with an increase in scotopic sensitivity particularly for category 1 (r=0.392) but also for category 2 (r=0.328). Both categories demonstrated a small correlation of the ONL thickness with photopic sensitivity (category 1: r=0.223, category 2: r=-0.209).
Conclusions: Within areas with RDR, correlations between structural and functional changes can be observed. A decrease in ONL thickness seems to be correlated with a reduction in rod function.
