gms | German Medical Science

VI. International Symposium on AMD – Age-Related Macular Degeneration – Emerging Concepts – Exploring known and Identifying new Pathways

11. - 12.09.2015, Baden-Baden

Parainflammation and macrophages modulation in AMD

Meeting Abstract

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  • Andrew Dick - Bristol

VI. International Symposium on AMD – Age-Related Macular Degeneration – Emerging Concepts – Exploring known and Identifying new Pathways. Baden-Baden, 11.-12.09.2015. Düsseldorf: German Medical Science GMS Publishing House; 2015. Doc15amd19

doi: 10.3205/15amd19, urn:nbn:de:0183-15amd193

Veröffentlicht: 1. Oktober 2015

© 2015 Dick.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Text

Progression of age-related macular degeneration (AMD) includes hallmarks of retinal pigment epithelium and photoreceptor loss accompanied by unchecked immune response and degeneration or pathological angiogenesis. While the current paradigm converges to associate complement dysregulation and inflammasome activation as major components of immune responses, we interrogate the specific mechanisms of action of macrophage and myeloid cells within the retina. This includes introducing the notion of a protective parainflammatory response. To that end we have shown how macrophages are early infiltrating cells that engulf dying RPE and drive angiogenesis and that this response may be subverted through cytokine modulation ((L-4, IL-33) of macrophage function or through activation of inhibitory receptors (CD200R). Furthermore our investigations have shown that it is the nature of RPE degeneration (oxidative stress, bio-energetic switching or impaired autophagy) that differentially regulate macrophage phenotype and function.