gms | German Medical Science

GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V. (DGHNOKHC)

ISSN 1865-1038

Differential expression of D2-40 and E-Cadherin in head and neck squamous cell carcinoma

Poster Onkologie

  • corresponding author Amalia Raluca Balica - "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania
  • Nicolae Constantin Balica - "Victor Babes" University of Medicine and Pharmacy Timisoara, RO, Timisoara, Romania
  • Anca Maria Cimpean - "Victor Babes" University of Medicine and Pharmacy Timisoara, RO, Timisoara, Romania
  • Pusa Nela Gaje - "Victor Babes" University of Medicine and Pharmacy Timisoara, RO, Timisoara, Romania
  • Horatiu Eugen Stefanescu - "Victor Babes" University of Medicine and Pharmacy Timisoara, RO, Timisoara, Romania
  • Marioara Poenaru - "Victor Babes" University of Medicine and Pharmacy Timisoara, RO, Timisoara, Romania
  • Caius Doros - "Victor Babes" University of Medicine and Pharmacy Timisoara, RO, Timisoara, Romania
  • Marius Raica - "Victor Babes" University of Medicine and Pharmacy Timisoara, RO, Timisoara, Romania

GMS Curr Posters Otorhinolaryngol Head Neck Surg 2015;11:Doc365

doi: 10.3205/cpo001330, urn:nbn:de:0183-cpo0013304

Veröffentlicht: 16. April 2015

© 2015 Balica et al.
Dieser Artikel ist ein Open-Access-Artikel und steht unter den Lizenzbedingungen der Creative Commons Attribution 4.0 License (Namensnennung). Lizenz-Angaben siehe http://creativecommons.org/licenses/by/4.0/.


Gliederung

Abstract

Introduction: Head and neck squamous cell carcinoma (HNSCC) arise in the oral cavity, oropharyinx, larynx, hypopharynx and is the fifth leading cancer by incidence worldwide. No data are available about D2-40 expression discordances between basal cells of normal epithelium from different regions of head and neck and D2-40 differential expression in different subtypes of HNSCCs. Less studied in HNSCCs, E cadherins are involved in the tumour cell detachment from the primary tumour and basement membrane invasion. The aim of this work was to study D2-40 and E-cadherin expression in the tumor cells of HNSCCs with different localization.

Methods: We included in the study 32 biopsies from patients diagnosed with squamous cell carcinoma (well, moderate and poorly differentiated) from the larynx (14), pharynx (11), tongue base (2), lower lip (2), hard palate (1), gingival sulcus (1), nasal fossa (1). The immunoreaction for D2-40 and E- cadherin in the tumor cells was evaluated according with the following score: 0 (0% positive cells), 1 (<10% positive cells), 2 (10-30%), 3 (>30%).

Results: We found no D2-40 expression in tumor cells of poorly differentiated HNSCC. The maximum value of score- 3 was found in both moderately and well differentiated carcinoma of the tongue, and the value 1 of score was noticed in well and moderately differentiated laryngeal carcinoma. The value 3 of score for E- cadherin was showed in well differentiated squamous carcinoma of the tongue, larynx, lower lip, nasal fossa, hard palate. The alternance of areas without and reduced expression of E- cadherin was noticed in poorly differentiated carcinoma.

Conclusions: D2-40/E-cadherin association may be a potential phenotype for aggressiveness in head and neck squamous cell carcinoma.

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