gms | German Medical Science

26th Annual Meeting of the German Retina Society

German Retina Society

27.09.2013, Hamburg

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Circulating Melanoma Cells: An evolving instrument in the diagnostic of uveal melanoma

Meeting Abstract

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  • Salvatore Grisanti - Lübeck, Germany
  • J. Lüke - Lübeck, Germany
  • M. Reinsberg - Lübeck, Germany
  • A. Tura - Lübeck, Germany

Retinologische Gesellschaft. 26. Jahrestagung der Retinologischen Gesellschaft. Hamburg, 27.-27.09.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. Doc13rg27

doi: 10.3205/13rg27, urn:nbn:de:0183-13rg271

Published: August 20, 2013

© 2013 Grisanti et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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We previously determined the presence of circulating melanoma cells (CMCs) in uveal melanoma patients without metastatic disease and correlated the presence with other prognostic risk factors. The aim of this study was to further evaluate CMCs in uveal melanoma patients as diagnostic and prognostic tool. Successful identification of circulating tumor cells was correlated with characteristics of the primary tumor and cultured cells. Different markers were evaluated both in the primary tissues as well as in the propagated cultured cells. A good correlation between the examined tissue and cell samples was shown. The detection of CMCs is a useful tool for prognostic evaluation and determination of therapeutic strategies.