gms | German Medical Science

21st Annual Meeting of the German Retina Society and 8th Symposium of the International Society of Ocular Trauma (ISOT)

German Retina Society
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

Long-term results of limbal allograft transplantation in patients with limbal stem cell deficiency after chemical/thermal burns

Meeting Abstract

  • Ivan Chernetskiy - Moscow/Russia
  • P. Makarov - Moscow/Russia
  • R. Gundorova - Moscow/Russia

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008V059

The electronic version of this article is the complete one and can be found online at:

Published: June 18, 2008

© 2008 Chernetskiy et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Purpose: To study the outcomes of limbal allograft transplantation in patients with limbal stem cell deficiency.

Methods: Limbal allograft transplantations on 31 eyes (27 patients) with limbal stem cell deficiency was performed from 8 months to 29 years. On 26 (83,9%) eyes annular allograft transplantation and on 5 (16,1%) eyes partial allograft transplantation was accomplished. The visual acuity before operation has formed light perception or hand movement. All patients received systemic cyclosporin A. Lamellar keratoplasties were performed in 2 cases and penetrating keratoplasties in 4 cases. The follow-up period was ranged from 3 months to 3 years.

Results: Corneal surface stability was in 5 cases in the remote observation. The visual acuity improvement took place in all patients with transparent cornea. 4 patients had development of thin avascular tissue after one year of the observation. Partial conjunctivalization took place in 5 cases after 1,5 years after limbal allograft transplantation. Total conjunctivalization and stromal vascularisation observed in 2 cases before one year and in 5 cases after year of the observation. Contours of transplant were noticeable less than one year in 12 cases, before two years in 6 patients, after two years also in 6 patients.

Conclusions: Allolimbal donation is an effective method of correction of limbal stem cell insufficiency. Probability of decompensation of transplant increase with long time of observation.