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21st Annual Meeting of the German Retina Society and 8th Symposium of the International Society of Ocular Trauma (ISOT)

German Retina Society
International Society of Ocular Trauma

19.06. - 22.06.2008, Würzburg

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Long-term results of limbal allograft transplantation in patients with limbal stem cell deficiency after chemical/thermal burns

Meeting Abstract

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  • Ivan Chernetskiy - Moscow/Russia
  • P. Makarov - Moscow/Russia
  • R. Gundorova - Moscow/Russia

Retinologische Gesellschaft. International Society of Ocular Trauma. 21. Jahrestagung der Retinologischen Gesellschaft gemeinsam mit dem 8. Symposium der International Society of Ocular Trauma. Würzburg, 19.-22.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocISOTRG2008V059

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/rg2008/08rg061.shtml

Published: June 18, 2008

© 2008 Chernetskiy et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

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Purpose: To study the outcomes of limbal allograft transplantation in patients with limbal stem cell deficiency.

Methods: Limbal allograft transplantations on 31 eyes (27 patients) with limbal stem cell deficiency was performed from 8 months to 29 years. On 26 (83,9%) eyes annular allograft transplantation and on 5 (16,1%) eyes partial allograft transplantation was accomplished. The visual acuity before operation has formed light perception or hand movement. All patients received systemic cyclosporin A. Lamellar keratoplasties were performed in 2 cases and penetrating keratoplasties in 4 cases. The follow-up period was ranged from 3 months to 3 years.

Results: Corneal surface stability was in 5 cases in the remote observation. The visual acuity improvement took place in all patients with transparent cornea. 4 patients had development of thin avascular tissue after one year of the observation. Partial conjunctivalization took place in 5 cases after 1,5 years after limbal allograft transplantation. Total conjunctivalization and stromal vascularisation observed in 2 cases before one year and in 5 cases after year of the observation. Contours of transplant were noticeable less than one year in 12 cases, before two years in 6 patients, after two years also in 6 patients.

Conclusions: Allolimbal donation is an effective method of correction of limbal stem cell insufficiency. Probability of decompensation of transplant increase with long time of observation.