gms | German Medical Science

The timing of performing the primary surgery (PS) of the open-globe injury (OGI) involving posterior segment is a matter of dispute. Some specialists support a stage-by-stage approach: immediate PS with further vitreoretinal surgery procedure (VRS) at a vitreoretinal centre, if required. As for the opponents to the above approach, they recommend delayed PS with simultaneous reconstructing VRS.Purpose of the research: Determination of the optimal timing of PS with OGI involving posterior segment.

Research materials and methods: The work was performed in accordance with International Recommendations on Medical-and-Biologic Research. Methods applied were clinic and cytologic research. Experimental material groups: Groups I, II, III and IV – rabbits’ eyes to simulate standard OGI approximated to ocular war injuries with localization in zone II. After 12, 24, 48, 72 hrs following the injury PS was applied, accordingly. On the 30th day following the injury enucleation was performed.

Research results: The research showed that with the animal material of Groups II and III fibrinous-and-inflammatory and proliferation responses of intraocular structures were less expressed, as compared to animal material of Groups I and IV.

Conclusion: Both the PS for OGI involving posterior segment after over 2 days and surgery treatment within the first 12 hrs following the injury affect the course of eye wound healing.