gms | German Medical Science

48th Meeting of the Particle Therapy Co-Operative Group

Particle Therapy Co-Operative Group (PTCOG)

28.09. - 03.10.2009, Heidelberg

Proton Radiation Therapy for Pediatric Chordoma of the Cranial Base

Meeting Abstract

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  • N. J. Liebsch - Radiation Oncology, Massachusetts General Hospital, Boston, USA

PTCOG 48. Meeting of the Particle Therapy Co-Operative Group. Heidelberg, 28.09.-03.10.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. Doc09ptcog122

DOI: 10.3205/09ptcog122, URN: urn:nbn:de:0183-09ptcog1222

Published: September 24, 2009

© 2009 Liebsch.
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Outline

Text

From 1981 to 2008, N=105 children (46 males, 59 females) have received postoperative high-dose fractionated photon-proton RT with curative intent at the Massachusetts General Hospital. The median time from the onset of symptoms and signs to diagnosis was 4.9 months. The 105 children underwent 227 tumor resections prior to RT, among them 38 resections for tumor progression. 23 children required dorsal occipital-cervical stabilizations. The median residual tumor volume was 36.8 cc. The median tumor dose was TD=78.5 +/- 3.3 Gy(RBE), delivered in 1.8–2.0 Gy(RBE)/fraction. Dose constraints of normal anatomical structures were: optic pathway: <62 Gy(RBE); brain stem/spinal cord – surface: <67 Gy(RBE), center: <55 Gy(RBE). Median follow-up: 9.5 years. Local tumor control is: 81% at 5 years, 78% at 10 years, 72% at 15 and 20 years. Overall survival is 76% at 10 years, 64% at 20 years. Interdisciplinary management of pediatric chordoma of the cranial base and outcome results will be discussed in detail.