Article
Are Brugada type I and type II signs on standard electrocardiography in patients with arrhythmic right ventricular cardiomyopathy suggestive of Brugada syndrome?
Search Medline for
Authors
Published: | February 8, 2007 |
---|
Outline
Text
Aim: standard electrocardiography ( ECG)with Brugada type I and Brugada type II signs in patients( pts ) with proved ( echocardiography, cardiac catheterism, magnetic resonance –MRI ) arrhythmic right ventricular cardiomiopathy(ARVC).
Material: 9 pts ( 4F, 5 M ) aged 28 – 52y with ARVC diagnosed by 2D / Doppler echocardiography, cardiac catheterism, MRI and Brugada type I( 3 pts) , Brugada type II( 6 pts) signs on standard ECG.
Method: standard 12 lead ECG; high right precordial (V1,V2,V3) leads; ambulatory monitoring (Holter 24 h) for heart rate / ventricular/supraventricular arrhythmias; provocative test for Brugada type I –Ajmaline 1 mg/kg; electrophysiologic study for ventricular tachycardia; genetic exam(blood ) for SCN5A / ARVC genes.
Results: Group I – ARVC and spontaneous Brugada type I sign(3pts). Group II – ARVC and spontaneous Brugada type II sign(6 pts). Positive provocative test(Ajmaline ) – 1 pt(Group II); negative provocative test(Ajmaline) – 5 pts( Group II). Holter 24 h – ventricular tachycardia LBBB type – 5 pts ( 3 group I,2 Group II ); polymorphic ventricular tachycardia, 1 pt (Group I); premature ventricular beats ,7 pts (4 Group I, 3 Group II). Electrophysiologic study 6 pts(3 Group I; 3 Group II) – ventricular tachycardia ,3 pts (group I). Genetic study – SCN5A positive ,1 pt( Group I ).
Conclusion: 1) Patients with ARVC have Brugada type I and Brugada type II signs on spontaneous ECG. 2) Only few of these pts have some other data (Ajmaline test, genetic test) sugestive of Brugada syndrome.