gms | German Medical Science

83rd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery

16.05. - 20.05.2012, Mainz

Primary surgical and non-surgical treatment of advanced stage laryngeal and hypopharyngeal carcinomas

Meeting Abstract

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  • corresponding author Pl Koltai - Nationalinstitut fr Onkologie, Budapest, Budapest, Ungarn
  • Csongor Lengyel - Nationalinstitut fr Onkologie, Budapest, Ungarn
  • va Remenr - Nationalinstitut fr Onkologie, Budapest, Ungarn
  • Andrs Bor - Nationalinstitut fr Onkologie, Budapest, Ungarn

Deutsche Gesellschaft fr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 83. Jahresversammlung der Deutschen Gesellschaft fr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Mainz, 16.-20.05.2012. Dsseldorf: German Medical Science GMS Publishing House; 2012. Doc12hnod252

doi: 10.3205/12hnod252, urn:nbn:de:0183-12hnod2523

Published: April 4, 2012

© 2012 Koltai et al.
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Outline

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Introduction: in the past two decades according to studies published in the early '90s the standard treatment of advanced laryngeal and hypopharyngeal carcinomas has been changed: instead of radical surgery larynx-preserving methods came into view.

Method and patients: to evaluate our results with this new approach we conducted a retrospective study summarizing the treatment data of the patients received non-surgical (n=44) or surgical (n=207) therapy for their advanced, resectable laryngeal or hypopharyngeal cancer in the National Institute of Oncology between 2002 and 2007. Non-surgical treatment consisted of platinum base chemoradiotherapy plus salvage surgery if needed, while as surgical treatment patients underwent laryngectomy with or without neck dissection followed by radiotherapy or chemoradiotherapy.

Results: with non-surgical treatment the one-year laryngoesophageal dysfunction (LED) free survival (the patient is alive with functioning larynx without local relapse, tracheostomy or feeding tube) is 82.9% (SD:0.0592), at 24 months 79.8% (SD:0.0645). Non-surgical treatment proved to be beneficial respecting distant metastases as well (9,09% in non-surgical and 27,08% in surgical group at two years, respectively). Formation of second primary tumor was more frequent in non-surgical group (11.36% vs 8,33%). There was no significant difference in overall survival between treatment groups if stratified according to primary tumor site and stage.

Conclusion: the results of larynx preserving treatments conducted in our Institute are similar to those published in the literature, confirming this method as standard therapy in this group of patients.