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7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation, Annual Assembly of the German and the Austrian Society of Physical Medicine and Rehabilitation

Austrian Society of Physical Medicine and Rehabilitation

26.-29.10.2011, Salzburg, Austria

Effect of antioxidant supplementation on muscle damage and oxidative stress markers in elite young soccer players

Meeting Abstract

  • corresponding author presenting/speaker Ivana Baralic - Institute for Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • author Brizita Djordjevic - Institute for Bromatology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • author Nenad Dikic - Sports Medicine Association of Serbia, Belgrade, Serbia
  • author Nenad Radivojevic - Sports Medicine Association of Serbia, Belgrade, Serbia
  • author Marija Andjelkovic - Sports Medicine Association of Serbia, Belgrade, Serbia
  • author Sinisa Vujic - Sports Medicine Association of Serbia, Belgrade, Serbia
  • author Jelena Kotur-Stevuljevic - Institute for MedicalBiochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • author Aleksandra Stefanovic - Institute for MedicalBiochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
  • author Jasmina Ivanisevic - Institute for MedicalBiochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation. Salzburg, 26.-29.10.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. Doc11esm068

DOI: 10.3205/11esm068, URN: urn:nbn:de:0183-11esm0685

Published: October 24, 2011

© 2011 Baralic et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.


Outline

Text

Objective: The purpose of the current study was to examine the effect of novel antioxidant -astaxanthin (Asx) on muscle enzymes as an indicators of muscle damage, oxidative stress markers and antioxidant response in elite young soccer players.

Material/Methods: 32 male elite soccer players (age 17.72±0.76 years) were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Asx group was supplemented with 4 mg of Asx. After the 90 days of supplementation, the soccer players performed 2 hour forced training. Blood samples were obtained at rest before supplementation and before and after the training at the end of observational period.

Results: Basal total antioxidative status TAS levels did not changed along the study. However, forced training induced significant decrease in TAS levels only in P group (p<0.01). Basal sulphydryl groups (SH) content increased significantly only in Asx group over the 90 days of supplementation (p<0.05). We observed significant decrease in basal superoxide-dismutase (SOD) activity (p<0.05) along with significant increase in superoxide anion (O2•¯) concentrations (p<0.05) both in P and in Asx group by the end of the study. However, forced training caused additional increase in O2•¯ levels only in P group (p<0.05). Malondialdehyde (MDA) levels did not change throughout the study. All participants showed a significant decrease in basal plasma creatine kinase (CK) and aspartate aminotransferase (AST) activities after 90 days. Post-exercise significant elevations above resting values was observed for CK (p<0.01) and AST (p<0.01) only in P group, while remained practically unchanged in Asx group.

Conclusion: Asx supplementation may have favorable effect on preserving non-enzymatic antioxidant defense system from consumption by the oxidative process. Antioxidant activity of Asx can have potential benefits in neutralizing post-training rise in O2•¯, but without impact on lipid oxidation. Asx reduced post-training increment of CK and AST, which may suggest that the muscular damage was reduced. Based on our findings, supplementation with astaxanthin might be beneficial strategy in improving sport recovery and performance.


References

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Finaud J, Lac G, Filaire L. Oxidative Stress – Relationship with Exercise and Training. Sports Med. 2006;36(4):327-58.