gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

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Retinal circulation and local application of Phenylephrin

Meeting Abstract

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  • corresponding author J. Harazny - Friedrich-Alexander Universität Erlangen-Nürnberg, Augenklinik mit Poliklinik, Erlangen
  • G. Michelson - Friedrich-Alexander Universität Erlangen-Nürnberg, Augenklinik mit Poliklinik, Erlangen

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 167

The electronic version of this article is the complete one and can be found online at: http://www.egms.de/en/meetings/dog2004/04dog658.shtml

Published: September 22, 2004

© 2004 Harazny et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.

Outline

Text

Objective

Phenylephrin (Neosinephrin-POS 5%) is an alpha1-agonist that is used regulary to widen the pupil. Application of Neosynephrin 10% eye drops decreased of the diameter of the vessels in the retina (Lanzl. Ith With Vilser W. Kotliar K.E. Berlin 99.DOG 2001). Purpose: Measurement of the retinal microcirculation by Scanning Doppler Flowmetry after local application of Neosinephrin-POS® 5% (Phenylephrin).

Methods

The capillar perfusion of the retina was measured by HRF (Retina Heidelberg Flowmetry). The analyses were carried out with AFFPIA. We evaluated: DC, flow entire, flow average, flow in big vessels, capillaries, capillar+intercapillar area. The number of the measurement points per picture was measured additional and the offset correction parameters a and b were analysed. Persons: 10 healthy persons in the age of year 46±13. Study design: We examined the retinal microcirculation before and after local application of Neosinephrin POS 5%. The images of the capillar circulation were made in the same areas of the retina before and 20 minutes after application of one drop Neosynephrin POS® 5% (Phenylephrin) into the right-eye. In 5 subjects we measured the retinal microzirculation after local application of phenylephrin every 10 minutes up to 40 minutes. The contralateral, undropped eye, was regarded as control.

Results

The DC-value, the number of the measurement points and the noise component showed no change within 20 minutes after local application of Phenylephrin. The retinal circulation decreased significantly about -36±12% (p=0.005), flow average about -31±16% (p=0.005), flow in the capillar+intercapillar area about -31±16% (p= 0.005). We observed the strongest effect 20 to 30 minutes after local application of Phenylephrin. After 40 minutes we have observed no normalisation of the retinal circulation.

Conclusions

Locally applied Neosynephrin POS® 5% decreases the capillar circulation in the retina ca. -30%.