gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Patent-Blue (Blueron) - a new dye for cataract surgery and chromovitrectomy: first results

Meeting Abstract

  • corresponding author S. Mennel - Philipps-University Marburg, Department of Ophthalmology
  • C. H. Meyer - Philipps-University Marburg, Department of Ophthalmology
  • E. B. Rodrigues - Philipps-University Marburg, Department of Ophthalmology
  • J. C. Schmidt - Philipps-University Marburg, Department of Ophthalmology
  • P. Kroll - Philipps-University Marburg, Department of Ophthalmology

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogSO.01.13

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Mennel et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




Dyes have gained importance in the last few years in chromovitrectomy and cataract surgery for the visualization of intraocular structures in which recognition have been difficult yet. Additionally to indocyanine green and trypan blue there is currently a third dye available for intraocular application, called patent blue.


In the anterior segment surgery we have used patent blue for staining the anterior lens capsule. In the first group the technique for dye application has followed the instructions of the manufacturer. After lens capsule staining under air fluid exchange was performed before viscoelastic was injected. In a second group the air was directly exchanged with viscoelastic. In the posterior pole we have injected patent blue for staining the epiretinal membranes of several pathogenesis as well as for internal limiting membrane staining. We evaluated both the intraoperative tissues visualization and also the histological analysis of the removed tissues.


Patent blue for the anterior segment surgery: whereas the lens capsule stained under air, it is removed by rinsing the anterior chamber with fluid. In cases of intumescent cataract the colouring was not enough for the accomplishment of a complete capsulorrhexis. However, when the air was directly exchanged with viscoelastics, then capsule staining was successfully accomplished. Patent blue for the posterior segment surgery: staining epiretinal membranes in a fluid-filled eye allowed their visualization only in few cases. In most cases of epiretinal membranes and internal limiting membranes staining no dye binding to the membrane could be achieved. Histological examinations revealed adequate membrane removal in all cases.


1. By rinsing the air filled anterior chamber patent blue is mostly removed and the visualization of the anterior capsule is not satisfactory. 2. Direct air-viscoelastic exchange allowed the anterior capsule to be enoughly stained. 3. The patent blue binding to the anterior capsule is poorer than with trypan blue. 4. The visualization enhancement of the pre-retinal structures is in only a few cases possible.