gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Ligneous conjunctivitis in a patient with plasminogen type I deficiency: case report

Meeting Abstract

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  • corresponding author P. Meyer - Universitäts-Augenklinik Basel, Basel/CH
  • S. Turtschi - Universitäts-Augenklinik Basel, Basel/CH
  • J. Messerli - Universitäts-Augenklinik Basel, Basel/CH

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogDO.13.02

The electronic version of this article is the complete one and can be found online at:

Published: September 22, 2004

© 2004 Meyer et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.




Ligneous conjunctivitis is a rare, chronic, recurrent pseudomembranous conjunctivitis forming nodular masses on the palpebral conjunctiva.


Case report with clinical and histopathological diagnostic findings.


A 31-year-old woman patient developed a therapy resistant, chronic conjunctivitis after intraocular surgery (secondary implantation of a posterior chamber lens). Large papillae with whitish deposits on the superior tarsal region were found. The tarsus was deformed by scaring lesions. Because of congenital cataract with secondary glaucoma, the patient was repeatedly operated on both eye. In November 2003, a surgical excision of the papillomatous deposits was performed with parallel cryotherapy of the tarsus. On histology, both granulation tissue with accompanying inflammatory infiltrate and necrotic areas and clotted fibrin deposits were found. The analysis of clotting parameter revealed a plasminogen deficiency of 17% compared to normal values. The conjunctivitis could be positively influenced by an after-treatment with a therapeutic contact lens and hyaluronic acid.


In chronic, therapy-resistant conjunctivitis with whitish, pseudomembranous, fibrin-rich deposits, especially after surgery, an early biopsy of the conjunctiva with histological examination is necessary. In suspect of conjunctivitis lignosa, the diagnosis can be confirmed by detection of a plasminogen type I deficiency.