Article
Pregabalin is superior than gabapentin in treating spinal morning stiffness pain originated from lumbar disc degeneration
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Published: | October 13, 2014 |
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Outline
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Purpose: To determine the efficacy of pregabalin vs gabapentin in treating morning lumbar spine stiffness pain attributed to lumbar disc degeneration.
Methods/subjects: A study of 96 patients with lumbar spine morning stiffness, presenting to our department, during the period between January 2009 and May 2013, were included. All patients were randomly assigned to receive either 300mg pregabalin daily (Group 1) or gabapentin 1200mg daily (Group 2) for 2 months. Clinical outcomes were measured with VAS pain scale and Roland-Morris Disability Questionnaire at baseline, 6 months, 1 and 2 years after. Statistical analysis was performed by statistical packet STATA 8.0 and significance was set at p-value <0.05.
Results: The VAS pain score decreased significantly from 7.5/10 to 2.3/10 in Group 1 (P<0.05) and from average 7.3/10 to 5.1/10 in Group 2 (p<0.05) at 2 years follow up. Roland Morris Disability decreased also significantly from average 17.8/24 to 2.4/24 in Group 1 (p<0.05) and from 17.1/24 to 6.2/24 in Group 2 (p<0.05) at 2 years follow up. Better clinical outcomes were observed in Group 1 (p<0.05).
Conclusion: Therapy with pregabalin provides efficient pain relief in patients suffering from lumbar spine morning stiffness.