gms | German Medical Science

27th German Cancer Congress Berlin 2006

German Cancer Society (Frankfurt/M.)

22. - 26.03.2006, Berlin

Chemokine receptors CXCR4 and CCR7 influence proliferation and dissemination of human hepatocellular cancer

Meeting Abstract

  • corresponding author presenting/speaker Carl Christoph Schimanski - Universitätsklinikum, Mainz, Deutschland
  • Rüdiger Bahre - Universitätsklinikum, Mainz
  • Andreas Teufel - Universitätsklinikum, Mainz
  • Nektaria Simiantonaki - Universitätsklinikum, Mainz
  • Vanessa Wilsberg - Universitätsklinikum, Mainz
  • Thomas Wehler - Universitätsklinikum, Mainz
  • Tobias Achenbach - Universitätsklinikum, Mainz
  • Peter R. Galle - Universitätsklinikum, Mainz
  • Markus Moehler - Universitätsklinikum, Mainz

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPE222

The electronic version of this article is the complete one and can be found online at:

Published: March 20, 2006

© 2006 Schimanski et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Lymphatic and distant metastases dramatically delineate the survival of hepatocellular carcinoma patients (HCC). Despite many pathophysiological analyses, the process of tumor dissemination of HCC remains vague. In diverse other tumor entities, expression of the chemokine receptors CXCR4 and CCR7 has been linked to tumor dissemination and poor prognosis. Therefore, we evaluated, if the expression of these chemokine receptors exerts similar effects in human HCC.

Patients and Methods: The expression of CXCR4 and CCR7 was evaluated in 39 patients with histologically confirmed hepatocellular cancer and cell lines (Huh7, HepG2, dominant negative transfected p53HepG2, Hep3B). Expression intensities of tumor samples were correlated with both, tumor and patients characteristics. In addition, in vitro functional assays were performed to elucidate the impact of SDF1-alpha on CXCR4 translocation.

Results: Human hepatocellular carcinoma samples and cell lines displayed variable intensities of CXCR4 and CCR7 expr.