Article
Impact of comorbidity on stage-specific long term survival and perioperative morbidity in surgical resected elderly non small cell lung cancer patients
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Published: | October 14, 2013 |
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Objective: To analyse the effect of comorbidity on stage specific long term survival and perioperative morbidity in NSCLC patients >75 years following lung resection.
Methods: Patients diagnosed with NSCLC > 75 years and primary lung resection between January 2002 and December 2012 were identified and medical records were analyzed retrospectively. To classify comorbidity the Charlson comorbidity index (CCI) was calculated. Mortality hazard ratios will be calculated using Cox proportional hazard modelling taking into consideration CCI, tumor stage, preoperative lung function, age and performance status.
Results: 219 patients with a mean age of 78.5±0.2 years were included in this study. 25% (55) of patients were octogenarians. NSCLC tumor stage was stage I in 53%, stage II in 22%, stage III in 21% and stage IV in 4% of patients. In 197 patients (90%) anatomic lung resections (lobectomy 79.5%, pneumonectomy 7.8%) and in 22 (10%) wedge resections were performed. Overall perioperative mortality was 1.4% and morbidity 16%. Overall mean CCI was 3.1±0.1. Mean overall survival in a subset of 90 patients with complete follow up was 24.9±2.6 month with a significantly prolonged mean survival time of 34.2±4.6 month in stage I patients.
Conclusion: Lung resections with curative intent in patients with lung cancer can be performed safely in patients >75 years with satisfying long term survival result.