gms | German Medical Science

Introduction: Gout is the most common inflammatory arthritis in adults worldwide, with a disproportionate burden of disease in men. Comorbidities are common in people with gout and complicate its management and disease outcomes.

Methods: The study included 286 male patients with gout: age 51.2 [42.8;59.4] years (ys), disease duration – 6.2 [3.8;12.1] ys. All patients underwent standard clinical examination, screening traditional risk factors (TRF) of CVD, blood chemistry test with estimation of serum uric acid, serum creatinine, C-reactive protein (CRP), as well as lipid profile. We studied incident congestive arterial hypertension (AH), coronary heart disease (CHD) included history of angina pectoris and/or myocardial infarction (MI), heart failure (CHF), ischemic or hemorrhagic stroke, metabolic syndrome. We estimated the adjusted odds ratio (OR) and 95% confidence interval (95% CI).

Results: AH was found in 243 out of the 286 pts (84.9 %), CHD – in 111 (38.8 %), MI – in 33 (11.5%), CHF – in 28 (9.8%), ischemic or hemorrhagic stroke – in 10 (3,5%), metabolic syndrome – in 156 (54.5%) pts. The frequency of family history of CVD – in 114 (39.8%) pts. Multivariate analysis demonstrated that abdominal obesity, family history of CVD, disease duration more 10 ys, intraosseous tophi, elevated C-RP, age of gout onset < 35 ys, renal failure in patients with a gout increased the risk for developing CVD, such as hypertension and CHD.

Conclusion: Our study showed that both TRFs of CVD and the severity of gout and a history of renal failure contribute to the development of CVD in patients with gout. Given that these cardiovascular co-morbidities may affect both clinical outcomes and the management of gout patients, their recognition and monitoring is of utmost importance.

Disclosures: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.