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Dorsal root ganglion stimulation (DRGS) relieves chronic neuropathic pain along with a decrease in cortical gamma power
Dorsalganglienstimulation (DRGS) reduziert chronische neuropathische Schmerzen unter gleichzeitiger Abnahme der kortikalen Gammabandaktivität
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Published: | June 4, 2021 |
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Objective: Gamma band oscillations reflect ongoing pain intensity in chronic pain patients. It was or hypothesis that dorsal root ganglion stimulation (DRGS) relieves chronic neuropathic pain along with a decrease in the broadband cortical gamma power.
Methods: We examined 9 patients (2 females, mean age 56.8 years; range 36 to 77 years) who were diagnosed with CNP and received DRGS therapy. We used the numeric rating scale (NRS) on the painful limb and simultaneously recorded electroencephalography (EEG) to measure broad-band gamma power. Measurements were taken on day 1 and 7.
Results: The resting state gamma power after DRGS revealed a significant decrease (p = .012) in the low gamma power between 30 – 45 Hz, recorded from the central electrodes from day 1 (M = 0.48, SD = 0.24) to day 7 (M = 0.31, SD = 0.12). High gamma-band power (55-95Hz) recorded from the frontal electrodes also decreased (p = .047) significantly from day 1 (M = 0.40, SD = 0.29) to day 7 (M = 0.23, SD = 0.11). We found a positive correlation between the low (rs = 0.528, p = .024) and high (rs = 0.292, p = .24) gamma power with CNP rating.
Conclusion: A decrease in the broadband gamma power may be considered as further evidence in favor of a reduction of the hyperexcitability of the nociceptive system in response to DRGS therapy. This is another important neurophysiological proof of the efficacy of DRGS.