gms | German Medical Science

68th Annual Meeting of the German Society of Neurosurgery (DGNC)
7th Joint Meeting with the British Neurosurgical Society (SBNS)

German Society of Neurosurgery (DGNC)

14 - 17 May 2017, Magdeburg

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Reward processing modulates subthalamic beta band activity in patients with Parkinson's disease

Meeting Abstract

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  • Henning Schroll - Neurology, Charité University Medicine, Berlin, Deutschland
  • Joachim Runge - Medizinische Hochschule Hannover, Neurochirurgische Klinik, Hannover, Deutschland
  • Axel Lipp - Charité – Universitätsmedizin Berlin, Neurologie, Berlin, Deutschland
  • Gerd-Helge Schneider - Klinik für Neurochirurgie, Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Deutschland
  • Joachim K. Krauss - Medizinische Hochschule Hannover, Neurochirurgische Klinik, Klinik für Neurochirurgie, Hannover, Deutschland
  • Fred Hamker - Computer Science, Chemnitz University of Technology, Chemnitz, Deutschland
  • Andrea Kühn - Charité – Universitätsmedizin Berlin, Campus Mitte, Klinik für Neurologie, Sektion Bewegungsstörungen und Neuromodulation, Berlin, Deutschland

Deutsche Gesellschaft für Neurochirurgie. Society of British Neurological Surgeons. 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS). Magdeburg, 14.-17.05.2017. Düsseldorf: German Medical Science GMS Publishing House; 2017. DocP 155

doi: 10.3205/17dgnc718, urn:nbn:de:0183-17dgnc7182

Published: June 9, 2017

© 2017 Schroll et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.

Outline

Text

Objective: Tonic dopamine levels modulate the power of beta oscillations in the subthalamic nucleus. The physiological role of this relationship, however, remains unclear. Phasic changes in dopamine may be caused by rewards.

Methods: Here, we investigated whether beta activity might therefore be related to reward processing. We recorded local field potentials (LFPs) from the subthalamic nuclei of 19 patients with Parkinson’s disease who performed a computer-based reinforcement-learning task. Afterwards, we correlated the magnitudes of patients’ obtained rewards with task-related power changes in their LFP oscillations.

Results: During reward presentation, beta activity was positively correlated with reward magnitudes. During responding, moreover, alpha and low beta activities were negatively correlated with previous reward magnitudes, while the likelihood of repeating the previous response correlated positively.

Conclusion: Our results thereby suggest a role of beta activity in the processing of rewards, while alpha and low beta activity might be involved in reward-based response adaptation.