gms | German Medical Science

Objective: DCM is the most common cause of spinal cord dysfunction worldwide. Despite significant global research interest, many patients remain significant handicapped by this condition. Our objective was to quantify research activity and the prevailing themes in DCM research over the last 20 years.

Method: We conducted a systematic review of clinical human trials exclusively on DCM, published since 1st January 1995. EMBASE and MEDLINE were searched for “Cervical” AND “Myelopathy”. Results (N=2633) were hand searched for inclusion. Initial research themes were taken from a previous review [1], and iteratively expanded. Study characteristics and research themes were recorded for shortlisted articles. Spearman’s Rho was used for correlations.

Results: 1396 trials were identified, which included a total of 4040741 patients. Research originated largely from Japan (31%), North America (23%) or China (11%). Most data concerned patients undergoing surgery (59%), and the predominant research theme was the type of surgery (71%). Other common themes included imaging (18%) and prognostication (7%). Research activity has increased over time (Rho=0.94, p=0.001) and the type of surgery remains its predominant theme across all years. Over the past ten years there has been increased research focus on imaging (Rho=0.754, p=0.007) and epidemiology (Rho=0.934, p<0.001). Over the same period that has been a decreased focus on electrophysiology (Rho=0.891, p<0.001).

Conclusion: DCM research activity is increasing, yet focus remains on the type of surgery. Imaging and electrophysiology are emerging research themes. References: [1] Davies BM et al. Reported Outcome Measures in Degenerative Cervical Myelopathy: A Systematic Review. PloS One. 2016;11(8).