Article
A common genetic variation at 10p12.31 near AF10/MLLT10 influences meningioma risk
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Published: | June 4, 2012 |
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Outline
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Objective: Meningiomas are adult brain tumors originating from the meningeal coverings of the brain and spinal cord and account for ~30% of all primary brain tumors. A ~3-fold increased risk of meningioma is seen in the relatives of meningioma patients. The authors conducted a genome-wide association study (GWAS) in order to identify common genetic variations which contribute to this genetic risk.
Methods: 270,875 SNPs (single nucleotide polymorphisms) were analyzed (Illumina Infinium HD Human660w-Quad, OmniExpress BeadChips) in 859 meningioma patients and 704 controls with validation (PCR KASPar chemistry) in two independent sample sets totaling 774 cases and 1,763 controls.
Results: A novel susceptibility locus for meningioma at 10p12.31 (rs12770228, near AF10/MLLT10; OR=1.39, CI: 1.25–1.51, Pcombined=4.7x10–11) was identified. AF10/MLLT10 participates in several chromosomal rearrangements which result in various leukemias.
Conclusions: This is the first GWAS for meningiomas. The study suggests an important role for a novel gene (i.e. AF10/MLLT10) in the pathogenesis of meningiomas.