gms | German Medical Science

63rd Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Japanese Neurosurgical Society (JNS)

German Society of Neurosurgery (DGNC)

13 - 16 June 2012, Leipzig

A common genetic variation at 10p12.31 near AF10/MLLT10 influences meningioma risk

Meeting Abstract

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  • M. Simon - Neurochirurgische Universitätsklinik, Universitätsklinikum Bonn, Bonn, Deutschland
  • S.E. Dobbins - Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
  • R.S. Houlston - Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom
  • Meningioma GWAS group

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS). Leipzig, 13.-16.06.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. DocSA.01.10

doi: 10.3205/12dgnc308, urn:nbn:de:0183-12dgnc3083

Published: June 4, 2012

© 2012 Simon et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Meningiomas are adult brain tumors originating from the meningeal coverings of the brain and spinal cord and account for ~30% of all primary brain tumors. A ~3-fold increased risk of meningioma is seen in the relatives of meningioma patients. The authors conducted a genome-wide association study (GWAS) in order to identify common genetic variations which contribute to this genetic risk.

Methods: 270,875 SNPs (single nucleotide polymorphisms) were analyzed (Illumina Infinium HD Human660w-Quad, OmniExpress BeadChips) in 859 meningioma patients and 704 controls with validation (PCR KASPar chemistry) in two independent sample sets totaling 774 cases and 1,763 controls.

Results: A novel susceptibility locus for meningioma at 10p12.31 (rs12770228, near AF10/MLLT10; OR=1.39, CI: 1.25–1.51, Pcombined=4.7x10–11) was identified. AF10/MLLT10 participates in several chromosomal rearrangements which result in various leukemias.

Conclusions: This is the first GWAS for meningiomas. The study suggests an important role for a novel gene (i.e. AF10/MLLT10) in the pathogenesis of meningiomas.