gms | German Medical Science

62nd Annual Meeting of the German Society of Neurosurgery (DGNC)
Joint Meeting with the Polish Society of Neurosurgeons (PNCH)

German Society of Neurosurgery (DGNC)

7 - 11 May 2011, Hamburg

Do statins reduce the risk of intracranial aneurysm development? A case-control study

Meeting Abstract

  • C. Fung - Universitätsklinik für Neurochirurgie, Inselspital, Bern, Schweiz
  • S. Marbacher - Universitätsklinik für Neurochirurgie, Inselspital, Bern, Schweiz; Klinik für Neurochirurgie, Kantonspital Aarau, Aarau, Schweiz
  • J.A. Schläppi - Universitätsklinik für Neurochirurgie, Inselspital, Bern, Schweiz
  • J. Hüsler - Institut für mathematische Statistik, Universität Bern, Bern, Schweiz
  • J. Beck - Universitätsklinik für Neurochirurgie, Inselspital, Bern, Schweiz
  • A. Raabe - Universitätsklinik für Neurochirurgie, Inselspital, Bern, Schweiz

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocDI.10.03

doi: 10.3205/11dgnc167, urn:nbn:de:0183-11dgnc1678

Published: April 28, 2011

© 2011 Fung et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( You are free: to Share – to copy, distribute and transmit the work, provided the original author and source are credited.



Objective: Recent studies in rats demonstrated that statins may have an inhibitory effect on intracranial aneurysm (IA) development. The purpose of this clinical study was to assess whether chronic (long-term) statin use is associated with a risk reduction of cerebral aneurysm formation in humans.

Methods: We performed a single centre retrospective case-control study using patients admitted in our institution from January 1, 2005, to December 31, 2008. A case was defined as a patient with initial diagnosis of IA. Three controls were matched to each case on age, gender, and index year. The primary exposure of interest was cumulative statin use. Conditional logistic regression was used to assess the relationship between statin intake and incidence of IA.

Results: 1200 patients were included in the study. No overall association was found between statin use and incidence of IA (OR = 1.08; 95% CI 0.69 to 1.69), nor when dichotomized into hydrophilic and lipophilic user or short (less than 12 months) and long duration (more than 36 months) of intake. Hypertension and smoking significantly increased the risk of IA development (OR = 4.02, 95% CI 2.49-6.45; OR = 1.67, 95% CI 1.02-2.72).

Conclusions: We found no association between the use of statins and incidence of IA. The results do not support recent experimental findings and suggest that statins may have no beneficial effect on IA suppression.